Center for Interdisciplinary Research, D Y Patil University, Kolhapur, India.
Dalton Trans. 2012 Mar 14;41(10):3060-71. doi: 10.1039/c2dt11835a. Epub 2012 Jan 25.
La(0.7)Sr(0.3)MnO(3) (LSMO) nanoparticles have been prepared using glycine and polyvinyl alcohol (PVA) as fuels. Their crystal structure, particle morphology and compositions are characterized using X-ray diffraction, transmission electron microscopy, field-emission electron microscopy and energy dispersive analysis of X-ray. They show a pseudo-cubic perovskite structure. The spherical particle sizes of 30 and 20 nm have been obtained from samples prepared by glycine and PVA respectively. The field cooled (FC) and zero field cooled (ZFC) magnetizations have been recorded from 5 to 375 K at 500 Oe and superparamagnetic blocking temperatures (T(B)) of 75 and 30 K are obtained from samples prepared by glycine and PVA respectively. Particle size distribution is observed from dynamic light scattering measurements. Dispersion stability of the particles in water is studied by measuring the Zeta potential with varying the pH of the medium from 1 to 12. Under induction heating experiments, a hyperthermia temperature (42-43 °C) is achieved by both the samples (3-6 mg mL(-1)) at magnetic fields of 167-335 Oe and at a frequency of 267 kHz. The bio-compatibility of the LSMO nanoparticles is studied on the L929 and HeLa cell lines by MTT assay for up to 48 h. The present work reveals the importance of synthesis technique and fuel choice on structural, morphological, magnetic, hyperthermia and biocompatible properties of LSMO and predicts the suitability for biomedical applications.
La(0.7)Sr(0.3)MnO(3)（LSMO）纳米粒子已使用甘氨酸和聚乙烯醇（PVA）作为燃料制备。使用 X 射线衍射、透射电子显微镜、场发射电子显微镜和 X 射线能谱分析对其晶体结构、颗粒形态和组成进行了表征。它们呈现出伪立方钙钛矿结构。分别使用甘氨酸和 PVA 制备的样品得到了 30nm 和 20nm 的球形颗粒粒径。在 500Oe 下从 5 到 375K 记录了场冷（FC）和零场冷（ZFC）磁化，分别从甘氨酸和 PVA 制备的样品中获得了 75 和 30K 的超顺磁体阻挡温度（T(B)）。从动态光散射测量中观察到了颗粒的粒径分布。通过测量介质 pH 值从 1 到 12 时的 Zeta 电位，研究了颗粒在水中的分散稳定性。在感应加热实验中，在磁场为 167-335Oe 和频率为 267kHz 时，两种样品（3-6mgmL(-1))都达到了 42-43°C 的高温。通过 MTT 测定法在 L929 和 HeLa 细胞系上研究了 LSMO 纳米粒子的生物相容性，最长可达 48 小时。本工作揭示了合成技术和燃料选择对 LSMO 的结构、形态、磁性、热疗和生物相容性的重要性，并预测了其在生物医学应用中的适用性。
