用于磁热疗的透明质酸包覆的LSMO纳米颗粒
LSMO Nanoparticles Coated by Hyaluronic Acid for Magnetic Hyperthermia.
作者信息
Chen Yuanwei, Wang Ying, Liu Xi, Lu Mai, Cao Jiangwei, Wang Tao
机构信息
Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou, 730000, China.
Key Laboratory of Opto-Electronic Technology and Intelligent Control, Ministry of Education, Lanzhou Jiaotong University, Lanzhou, 730070, China.
出版信息
Nanoscale Res Lett. 2016 Dec;11(1):538. doi: 10.1186/s11671-016-1756-3. Epub 2016 Dec 3.
Magnetic hyperthermia with the treating temperature range of 41-46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La Sr MnO, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated. It was found the HA-coated LaSrMnO, with particle diameter of ~100 nm, Curie temperature of 45 °C at a concentration 6 mg/ml, gave the optimal induction heating results. The heating temperature saturates at 45.7 °C, and the ESAR is 5.7 × 10 W/g · kHz · (kA/m) which is much higher than other reported results.
治疗温度范围为41 - 46°C的磁热疗是一种癌症治疗的替代疗法。在本文中，通过简单的水热法结合高能球磨技术制备了由具有靶向肿瘤细胞能力的透明质酸（HA）包覆的镧锶锰酸盐（LaSrMnO，0.25≤x≤0.35）磁性纳米颗粒。研究了HA包覆磁性纳米颗粒（MNPs）的晶体结构、形态、磁性及其在交变磁场下的加热能力。发现包覆HA的LaSrMnO，粒径约为100nm，居里温度为45°C，浓度为6mg/ml时，给出了最佳的感应加热结果。加热温度在45.7°C时饱和，比吸收率为5.7×10W/g·kHz·(kA/m)，远高于其他报道结果。
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