抗逆转录病毒限制因子。
Antiretroviral restriction factors.
机构信息
Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, United States.
出版信息
Curr Opin Virol. 2011 Dec;1(6):526-32. doi: 10.1016/j.coviro.2011.10.007.
Abstract
Studies of retroviruses have been instrumental in revealing the existence of an array of antiviral proteins, or restriction factors, and the mechanisms by which they function. Some restriction factors appear to specifically inhibit retrovirus replication, while others have a broader antiviral action. Here, we briefly review current understanding of the mechanisms by which several such proteins exert antiviral activity. We also discuss how retroviruses have evolved to evade or antagonize antiviral proteins, including through the action of viral accessory proteins. Restriction factors, their viral targets and antagonists have exerted evolutionary pressure on each other, resulting in specialization and barriers to cross-species transmission. Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit.
摘要
逆转录病毒的研究有助于揭示一系列抗病毒蛋白（或限制因子）的存在，以及它们发挥作用的机制。一些限制因子似乎专门抑制逆转录病毒的复制，而其他因子则具有更广泛的抗病毒作用。在这里，我们简要回顾了几种此类蛋白发挥抗病毒活性的机制的最新理解。我们还讨论了逆转录病毒如何通过病毒辅助蛋白的作用来逃避或拮抗抗病毒蛋白。限制因子、它们的病毒靶标和拮抗剂相互施加了进化压力，导致了专门化和跨物种传播的障碍。可能的是，这种最近发现的内在抗病毒免疫系统可能会被动员起来以获得治疗益处。
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