Nair Smita, Rein Alan
HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.
Virus Res. 2014 Nov 26;193:130-4. doi: 10.1016/j.virusres.2014.07.002. Epub 2014 Jul 10.
One of the most exciting areas in contemporary retrovirus research is the discovery of "restriction factors". These are cellular proteins that act after virus entry to inhibit infection by or replication of retroviruses (and other viruses and intracellular pathogens). We briefly discuss here three antiretroviral restriction factors in mice: Fv1, APOBEC3, and tetherin, touching on both biological and molecular aspects of these restriction systems.
当代逆转录病毒研究中最令人兴奋的领域之一是“限制因子”的发现。这些是细胞蛋白,在病毒进入后发挥作用,抑制逆转录病毒(以及其他病毒和细胞内病原体)的感染或复制。我们在此简要讨论小鼠中的三种抗逆转录病毒限制因子:Fv1、载脂蛋白B编辑酶催化多肽样3(APOBEC3)和束缚素,涉及这些限制系统的生物学和分子方面。