PGC-1 共激活因子在衰老骨骼肌和心脏中的作用。
The role of PGC-1 coactivators in aging skeletal muscle and heart.
机构信息
Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, FL, USA.
出版信息
IUBMB Life. 2012 Mar;64(3):231-41. doi: 10.1002/iub.608. Epub 2012 Jan 25.
Abstract
Aging is the progressive decline in cellular, tissue, and organ function. This complex process often manifests as loss of muscular strength, cardiovascular function, and cognitive ability. Mitochondrial dysfunction and decreased mitochondrial biogenesis are believed to participate in metabolic abnormalities and loss of organ function, which will eventually contribute to aging and decreased lifespan. In this review, we discuss what is currently known about mitochondrial dysfunction in the aging skeletal muscle and heart. We focused our discussion on the role of PGC-1 coactivators in the regulation of mitochondrial biogenesis and function and possible therapeutic benefits of increased mitochondrial biogenesis in compensating for mitochondrial dysfunction and circumventing aging and aging-related diseases.
摘要
衰老是细胞、组织和器官功能的逐渐衰退。这个复杂的过程常常表现为肌肉力量、心血管功能和认知能力的丧失。线粒体功能障碍和减少的线粒体生物发生被认为参与代谢异常和器官功能丧失，这最终将导致衰老和寿命缩短。在这篇综述中，我们讨论了目前已知的衰老骨骼肌和心脏中线粒体功能障碍的情况。我们的讨论重点是 PGC-1 共激活物在调节线粒体生物发生和功能中的作用，以及增加线粒体生物发生在补偿线粒体功能障碍、规避衰老和与衰老相关的疾病方面的可能治疗益处。
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