Stem Cell Program, Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, California 92093, USA.
Genes Dev. 2012 Jan 15;26(2):105-9. doi: 10.1101/gad.185280.111.
In a study in the December 15, 2011, issue of Genes & Development, Valenta and colleagues (pp. 2631-2643) constructed a series of β-catenin mutants that allowed them to separate β-catenin's activity as a mediator of Wnt signaling from its activity as cell adhesion component. In doing so, they uncovered some surprising properties of Wnt signaling.
在 2011 年 12 月 15 日出版的《基因与发育》杂志上的一项研究中，Valenta 及其同事（第 2631-2643 页）构建了一系列β-连环蛋白突变体，使他们能够将β-连环蛋白作为 Wnt 信号转导介质的活性与其作为细胞黏附成分的活性区分开来。通过这样做，他们揭示了 Wnt 信号转导的一些令人惊讶的特性。
