[纳米颗粒在亚膜血红蛋白构象研究中的应用]

[The use of nanoparticles for the study of conformations submembrane hemoglobin].

作者信息

Maksimov G V, Brazhe N A, Iusipovich A I, Parshina E Iu, Rodnenkov O V, Rubin A B, Levin G G, Bykov V A

出版信息

Biofizika. 2011 Nov-Dec;56(6):1099-104.

Abstract

The advantages and features of the integrated application of methods of atomic force microscopy, laser interference microscopy and Raman microscopy in the study of erythrocytes was discussed. For the successful application of Raman microscopy in surface enhanced Raman spectroscopy mode the silver colloids was using. The dependence of the enhancement of Raman signals from silver colloids size was demonstrated. The using of developed methods for clinic diagnostic was discussed.

摘要

讨论了原子力显微镜、激光干涉显微镜和拉曼显微镜方法在红细胞研究中的综合应用的优点和特点。为了在表面增强拉曼光谱模式下成功应用拉曼显微镜，使用了银胶体。证明了拉曼信号增强对银胶体尺寸的依赖性。讨论了所开发方法在临床诊断中的应用。