Strathclyde Institute for Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Expert Rev Pharmacoecon Outcomes Res. 2012 Feb;12(1):125-30. doi: 10.1586/erp.11.98.
Multiple and intensive demand measures in Scotland have appreciably enhanced prescribing efficiency for proton pump inhibitors (PPIs) and statins in 2007 versus 2001. Statin utilization enhanced by measures to increase doses prescribed, including the Quality and Outcome Framework (QoF).
Ascertain whether the plethora of measures continue to enhance prescribing efficiency for PPIs and statins. Second, assess whether the combined impact of the QoF targets and guidance enhances the prescribing of higher strength statins, mirroring the situation in England.
PPI and statin utilization measured in terms of defined daily doses (DDDs) and DDDs per 1000 inhabitants per day (2010 DDDs) between 2001 and 2010, number and strength of simvastatin and atorvastatin tablets dispensed, and reimbursed expenditure per DDD and 1000 inhabitants per year.
Expenditure per DDD for generic omeprazole in 2010 was 91% below the 2001 originator price, leading to expenditure per 1000 inhabitants for PPIs in 2010 to be 56% below 2001 despite a threefold increase in utilization. Expenditure per DDD for generic simvastatin in 2010 was 97% below the 2002 originator price. Expenditure per 1000 inhabitants for statins in 2010 only increased by 7% compared with 2001 despite a 6.2-fold increase in utilization. Utilization of higher strength statins has increased in recent years, with higher strength simvastatin (40 and 80 mg) accounting for 85% of total statins (DDD basis) in 2010.
Reforms appear to be working to further enhance prescribing efficiency. Utilization of higher strength statins in recent years should further improve outcomes.
2007 年,苏格兰采取了多项密集的需求措施,质子泵抑制剂 (PPI) 和他汀类药物的处方效率明显提高,与 2001 年相比。通过增加处方剂量的措施(包括质量和结果框架 (QoF))提高了他汀类药物的利用率。
确定是否有大量措施继续提高 PPI 和他汀类药物的处方效率。其次,评估 QoF 目标和指南的综合影响是否增强了更高强度他汀类药物的处方,反映了英格兰的情况。
2001 年至 2010 年期间,以定义日剂量 (DDD) 和每千居民每天 DDD(2010 年 DDD)衡量 PPI 和他汀类药物的使用情况,开出处方的辛伐他汀和阿托伐他汀片剂的数量和强度,以及每 DDD 和每千居民每年的报销支出。
2010 年通用奥美拉唑的 DDD 支出比 2001 年原研药价格低 91%,尽管使用率增加了三倍,但 2010 年每千居民的 PPI 支出仍比 2001 年低 56%。2010 年通用辛伐他汀的 DDD 支出比 2002 年原研药价格低 97%。尽管使用率增加了 6.2 倍,但 2010 年每千居民的他汀类药物支出仅比 2001 年增加 7%。近年来,高强度他汀类药物的使用有所增加,2010 年高强度辛伐他汀(40 和 80 毫克)占他汀类药物总用量(DDD 基础)的 85%。
改革似乎正在发挥作用,进一步提高处方效率。近年来高强度他汀类药物的使用应该会进一步改善治疗效果。