Scholtysek Carina, Krönke Gerhard, Schett Georg
Department of Internal Medicine 3, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany.
Inflamm Allergy Drug Targets. 2012 Jun;11(3):188-95. doi: 10.2174/187152812800392706.
Bone is a dynamic tissue undergoing constant remodelling and repair. Its homeostasis is regulated by a coordinated process executed by bone forming and bone resorbing cells. Apart from being a major component of the locomotive system, bone provides protection for internal organs and represents a main mineral storage. Furthermore, it houses the haematopoietic system and is hence essential for the body's immune response. In turn, the innate and adaptive immune system itself, critically affect bone homeostasis. This is most evident during chronic inflammatory diseases, such as Rheumatoid Arthritis, where bone mass is critically reduced. Recently the field of osteoimmunology, focusing on this crosstalk between the immune system and bone homeostasis, has gained increasing attention. This review will highlight cellular and molecular mechanisms linking the innate and adaptive immune response to bone biology and provide an overview about involved cytokines and cells. Moreover, chronic inflammation and its consequences for bone turnover are discussed.
骨骼是一种动态组织，不断进行重塑和修复。其稳态由成骨细胞和骨吸收细胞执行的协调过程调节。骨骼除了是运动系统的主要组成部分外，还为内部器官提供保护，并代表主要的矿物质储存。此外，它容纳造血系统，因此对身体的免疫反应至关重要。反过来，先天性和适应性免疫系统本身也会严重影响骨骼稳态。这在慢性炎症性疾病（如类风湿性关节炎）中最为明显，此时骨量会严重减少。最近，专注于免疫系统与骨骼稳态之间这种相互作用的骨免疫学领域越来越受到关注。本综述将重点介绍将先天性和适应性免疫反应与骨骼生物学联系起来的细胞和分子机制，并概述相关的细胞因子和细胞。此外，还将讨论慢性炎症及其对骨转换的影响。
