Verma Sristi, Sinha Reema, Kumar Puspendra, Amin Faizal, Jain Jainendra, Tanwar Shivani
Ram-Eesh Institute of Vocational and Technical Education, Greater Noida, Uttar Pradesh, India.
Cent Nerv Syst Agents Med Chem. 2012 Mar;12(1):55-9. doi: 10.2174/187152412800229161.
Convolvulus pluricaulis Choisy is a perennial wild herb commonly found on sandy & rocky areas under xerophytic conditions in northern India. It is a reputed drug of ayurveda and reported to posses antioxidant, brain tonic, nervine tonic, laxative and has been used in anxiety, neurosis, epilepsy, insomnia, burning sensation, oedema and urinary disorders. In the present study, methanolic extract of whole plant of Convolvulus pluricaulis Choisy was evaluated for antioxidant activity by using 1, 1-diphenyl-2-picryl- hydrazyl (DPPH) free radical scavenging model and anticonvulsant activity by using maximal electroshock seizure model. In antioxidant activity, ascorbic acid was used as standard agent while results of anticonvulsant studies were compared with phenytoin. Results of antioxidant activity have demonstrated significant free radical scavenging effect for methanolic extract of Convolvulus pluricaulis Choisy. IC50 value of methanolic extract was observed as 41.00μg/ml as compared to 2.03μg/ml of ascorbic acid. Methanolic extract of C. pluricaulis was evaluated for anticonvulsant activity at 250, 500 and 1000mg/kg. Experimental results have shown that at the dose of 500 and 1000mg/kg, C. pluricaulis didn't abolish the hind limb extension, but reduced the mean recovery time from convulsion.
旋花是一种多年生野生草本植物，常见于印度北部旱生条件下的沙地和岩石地区。它是阿育吠陀中一种著名的药物，据报道具有抗氧化、补脑、滋补神经、通便作用，并且已被用于治疗焦虑、神经症、癫痫、失眠、烧灼感、水肿和泌尿系统疾病。在本研究中，采用1,1-二苯基-2-苦基肼基（DPPH）自由基清除模型评估了旋花全株甲醇提取物的抗氧化活性，并采用最大电休克惊厥模型评估了其抗惊厥活性。在抗氧化活性实验中，以抗坏血酸作为标准剂，同时将抗惊厥研究结果与苯妥英进行比较。抗氧化活性结果表明，旋花甲醇提取物具有显著的自由基清除作用。旋花甲醇提取物的IC50值为41.00μg/ml，而抗坏血酸的IC50值为2.03μg/ml。以250、500和1000mg/kg的剂量评估了旋花甲醇提取物的抗惊厥活性。实验结果表明，在500和1000mg/kg的剂量下，旋花并没有消除后肢伸展，但缩短了惊厥后的平均恢复时间。
