Dhar Arnab, Maurya Santosh Kumar, Mishra Ashish, Singh Gireesh Kumar, Singh Manoj Kumar, Seth Ankit
Department of Ayurvedic Pharmacy, Ayurvedic Pharmacy Laboratory, Rajiv Gandhi South Campus, Banaras Hindu University, Mirzapur, Uttar Pradesh, India.
Department of Kriya Shareer, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Mirzapur, Uttar Pradesh, India.
Anc Sci Life. 2016 Jul-Sep;36(1):28-34. doi: 10.4103/0257-7941.195410.
Epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmitters level in the brain. The available treatments are neither competent to control the seizures nor prevent progress of disease. Since ages, Herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional systems of medicine i.e. Ayurveda, Siddha, Unani, Homeopathy and Chinese etc.
A polyherbal formulation (containing Retz., Willd., Burm. F, L., (Willd.) Miers, Choisy, C.B.Clarke, L.) is mentioned in Ayurvedic classics . The aim of the study was to evaluate the anticonvulsant activity of the formulation in Maximum electroshock and Pentylenetetrazole induced convulsions in rats.
In the present study, a polyherbal formulation was developed as directed by classical text and evaluated for the anticonvulsant activity using Maximal Electroshock Shock (MES) and Pentylenetetrazole (PTZ) induced convulsions in rats. Statistical comparison was done by one way ANOVA followed by the Tukey's multiple comparison test.
The obtained results showed that the PHF had a protective role on epilepsy. Treatment with PHF significantly improves antioxidant enzymes activities of superoxide dismutase (SOD) and glutathione (GSH) levels significantly as compared to controls. PHF also significantly decreased malonaldialdehyde (MDA) levels in the brain. Moreover, it also attenuated the PTZ-induced increase in the activity of GABA-T in the rat brain.
These findings suggest that PHF might have possible efficacy in the treatment of epilepsy.
癫痫是一种严重且复杂的中枢神经系统疾病，与大脑中兴奋性（谷氨酸能）和抑制性（γ-氨基丁酸能）神经递质水平失衡导致的惊厥性发作反复发作有关。现有的治疗方法既无法有效控制癫痫发作，也不能阻止疾病进展。长期以来，草药在世界许多地区一直是重要的药物来源，这在传统医学体系如阿育吠陀医学、悉达医学、尤那尼医学、顺势疗法和中医等中的应用得到了证明。
一种多草药配方（包含 、 、 、 、 、 、 、 ）在阿育吠陀经典中被提及。本研究的目的是评估该配方在大鼠最大电休克和戊四氮诱导惊厥中的抗惊厥活性。
在本研究中，按照经典文献指导开发了一种多草药配方，并使用大鼠最大电休克（MES）和戊四氮（PTZ）诱导惊厥来评估其抗惊厥活性。通过单因素方差分析和 Tukey 多重比较检验进行统计学比较。
所得结果表明该多草药配方对癫痫具有保护作用。与对照组相比，用该多草药配方治疗可显著提高超氧化物歧化酶（SOD）和谷胱甘肽（GSH）水平的抗氧化酶活性。该多草药配方还显著降低了大脑中丙二醛（MDA）的水平。此外，它还减弱了 PTZ 诱导的大鼠大脑中γ-氨基丁酸转氨酶（GABA-T）活性的增加。
这些发现表明该多草药配方可能对癫痫治疗具有潜在疗效。
