Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA 92521-0124, USA.
Trends Plant Sci. 2012 Mar;17(3):129-38. doi: 10.1016/j.tplants.2011.12.004. Epub 2012 Jan 24.
Plant-specific group VII Ethylene Response Factor (ERF) transcription factors have emerged as pivotal regulators of flooding and low oxygen responses. In rice (Oryza sativa), these proteins regulate contrasting strategies of flooding survival. Recent studies on Arabidopsis thaliana group VII ERFs show they are stabilized under hypoxia but destabilized under oxygen-replete conditions via the N-end rule pathway of targeted proteolysis. Oxygen-dependent sequestration at the plasma membrane maintains at least one of these proteins, RAP2.12, under normoxia. Remarkably, SUB1A, the rice group VII ERF that enables prolonged submergence tolerance, appears to evade oxygen-regulated N-end rule degradation. We propose that the turnover of group VII ERFs is of ecological relevance in wetland species and might be manipulated to improve flood tolerance of crops.
植物特有的 VII 类乙烯响应因子（ERF）转录因子已成为水淹和低氧响应的关键调节因子。在水稻（Oryza sativa）中，这些蛋白质调节着水淹存活的相反策略。最近对拟南芥（Arabidopsis thaliana）VII 类 ERF 的研究表明，它们在低氧条件下稳定，但在富氧条件下通过靶向蛋白水解的 N 端规则途径不稳定。在质膜上的氧依赖性隔离至少维持了其中一种蛋白质 RAP2.12 在常氧条件下。值得注意的是，使水稻能够耐受长时间淹水的 VII 类 ERF SUB1A，似乎逃避了氧调节的 N 端规则降解。我们提出，VII 类 ERF 的周转率在湿地物种中具有生态相关性，并且可能被操纵来提高作物的耐水淹能力。
