Department of Neurobiology, Physiology and Behavior and Department of Mathematics, University of California, Davis, CA 95616, USA.
Curr Biol. 2012 Jan 24;22(2):R48-51. doi: 10.1016/j.cub.2011.12.013.
A combination of biophysical perturbations and computer simulations shows that leading edge protrusion in crawling cells increases membrane tension, which constrains the protruding front to one side of the cell, thereby maintaining its polarity.
生物物理扰动和计算机模拟的结合表明，爬行细胞的前缘突出会增加细胞膜张力，这会将突出的前缘约束在细胞的一侧，从而保持其极性。
