Mayo Clinic Cancer Center, Rochester, MN 55905, USA.
Semin Oncol Nurs. 2012 Feb;28(1):10-28. doi: 10.1016/j.soncn.2011.11.003.
To review clinical trials in natural products and mind-body therapies for oncology symptom management, to discuss issues related to developing clinical trials in this area, and outline examples of rigorous and innovative study design.
Peer reviewed literature.
Most of the evidence for the integrative therapies reviewed is derived from phase II trials, and is considered preliminary. More research is needed in these therapies to clearly articulate their role in the management of oncology symptoms. Innovative strategies and methodologies for studying integrative therapies have been demonstrated.
It is necessary to critically evaluate the literature to be able to educate patients about integrative therapies. Investigators should expand on well-designed studies that demonstrate clinically important effects. Dissemination trials may be a good strategy, once data exists, to move integrative therapies into the care of patients.
回顾天然产物和身心疗法在肿瘤症状管理方面的临床试验，讨论在该领域开展临床试验的相关问题，并概述严格创新的研究设计实例。
同行评议文献。
所审查的综合疗法的大部分证据来自 II 期临床试验，被认为是初步的。这些疗法需要更多的研究，以明确其在肿瘤症状管理中的作用。已经展示了用于研究综合疗法的创新策略和方法。
有必要批判性地评估文献，以便能够向患者传授有关综合疗法的知识。研究人员应该在已经证明具有临床重要意义的效果的精心设计的研究的基础上进行扩展。一旦有数据，传播试验可能是将综合疗法应用于患者护理的一个好策略。
