Kaldor J M, L'Abbé K A
International Agency for Research on Cancer, Lyon, France.
IARC Sci Publ. 1990(104):35-43.
In the absence of direct information on the carcinogenicity of a complex mixture, assessment of its risk requires not only knowledge of the risks due to the separate components, but also assumptions about the interaction between the components. A formal definition of interaction is given, followed by a discussion of the theoretical basis for different kinds of interactions. Epidemiological studies which have considered the simultaneous effect of two chemical carcinogens are reviewed, and shown to provide examples of additivity, multiplicativity and interaction both intermediate between the two and greater than multiplicative. Finally, implications for the risk assessment of mixtures are discussed.
在缺乏关于复杂混合物致癌性的直接信息时，对其风险的评估不仅需要了解各单独成分所致的风险，还需要对各成分之间的相互作用进行假设。给出了相互作用的正式定义，随后讨论了不同类型相互作用的理论基础。对考虑两种化学致癌物同时作用的流行病学研究进行了综述，结果表明这些研究提供了相加、相乘以及介于两者之间和大于相乘的相互作用的实例。最后，讨论了对混合物风险评估的影响。
