Anderson D
BIBRA, Carshalton, Surrey, UK.
IARC Sci Publ. 1990(104):89-100.
Since it is not feasible to test all substances in long-term animal studies, short-term tests for DNA damage, gene mutation, aneuploidy, chromosomal damage and cell transformation performed in prokaryotes and eukaryotes in vitro and in vivo are used to test pure chemicals and mixtures. Understanding the contribution of mutagens in air, water and food is important to our way of life; methods of sampling and testing such mutagens are discussed in this review.
由于在长期动物研究中对所有物质进行测试是不可行的，因此利用在原核生物和真核生物体内外进行的DNA损伤、基因突变、非整倍体、染色体损伤和细胞转化的短期测试来检测纯化学品和混合物。了解空气、水和食物中诱变剂的作用对我们的生活方式很重要；本综述讨论了此类诱变剂的采样和测试方法。
