Krogulski A
Zakładu Higieny Komunalnej Państwowego Zakładu Higieny, Warszawie.
Rocz Panstw Zakl Hig. 1992;43(3-4):271-5.
The increasing exposure of the human population to mutagen and carcinogenic substances necessitates research and introduction of methods for their detection. The diversity of these dangerous substances in the environment requires, the application of the chemical and biological tests. The latter allow testing of chemical mixtures of unknown composition. The advantages and limitations of short-term tests are presented. Among these the advantages of somatic mutation and recombination tests are described in more detail on Drosophila melanogaster. The subcellular structure, enzymes produced and the course of metabolic processes in Drosophila are similar as in man. It is possible, therefore, to detect the numerous mutagens undetectable in tests on bacteria. These test are relatively simple, not expensive and do not require expensive apparatus or preliminary activation of promutagens necessary in tests on bacteria.
人类接触诱变剂和致癌物质的情况日益增加，因此有必要开展相关研究并引入检测方法。环境中这些危险物质的多样性要求应用化学和生物学检测方法。后者能够对成分未知的化学混合物进行检测。本文介绍了短期检测的优缺点。其中，对果蝇的体细胞突变和重组检测的优点进行了更详细的描述。果蝇的亚细胞结构、产生的酶以及代谢过程与人类相似。因此，有可能检测出在细菌检测中无法检测到的多种诱变剂。这些检测相对简单、成本不高，并且不需要细菌检测中所需的昂贵仪器或前诱变剂的预激活。
