Sampaio Ana Luisa Sobral Bittencourt, Mameri Angela Cristina Akel, Vargas Thiago Jeunon de Sousa, Ramos-e-Silva Marcia, Nunes Amanda Pedreira, Carneiro Sueli Coelho da Silva
Federal University of Rio de Janeiro, Brazil.
An Bras Dermatol. 2011 Nov-Dec;86(6):1061-71; quiz 1072-4. doi: 10.1590/s0365-05962011000600002.
Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment.
脂溢性皮炎是一种慢性复发性红斑鳞屑性皮肤病，在美国普通人群中的患病率约为1%至3%。它有两个发病高峰，第一个在出生后的头三个月，第二个始于青春期，并在40至60岁时达到顶峰。脂溢性皮炎在HIV阳性个体中的患病率较高，而且在这些患者中病情往往更严重且治疗效果较差。神经系统疾病和其他慢性疾病也与脂溢性皮炎的发病有关。目前关于该病发病机制的公认理论认为，存在于易感个体皮肤表面的马拉色菌属酵母菌，由于其产生沉积在皮肤表面的不饱和脂肪酸，导致非免疫原性刺激。本文对脂溢性皮炎的文献进行综述，重点关注免疫遗传学、该病的临床形式及其治疗。
