The Jikei University School of Medicine, #303/6-13-7 Honkomagome, Bunkyo-Ku, Tokyo 113-0021, Japan.
Gastric Cancer. 2012 Oct;15(4):396-404. doi: 10.1007/s10120-011-0129-y. Epub 2012 Jan 27.
We conducted a survey regarding irregular bowel movement in gastrectomized patients. Their defecation frequency, intestinal microflora, and intestinal environment were studied and compared with those of healthy controls.
As a first step, a questionnaire survey on bowel movement, involving 769 patients and 312 healthy controls (total: 1,081 subjects), was carried out. As a second step, the defecation frequency (scoring of the survey results conducted to evaluate the state of constipation/diarrhea), intestinal microflora, and intestinal environment were evaluated in 190 gastrectomized patients with irregular bowel movement and 31 controls identified in the first survey.
First step: Of the 769 patients, 58% complained of irregular bowel movements (constipation, diarrhea, or their alternate occurrence), and their frequency of complaints was significantly higher (p < 0.01) than that in the healthy controls (33%). Second step: The levels of the most predominant obligate anaerobe and harmful bacteria in the feces were lower and higher, respectively, the fecal pH was lower, the fecal water content was lower, and the level of putrefactive metabolites in the feces was higher in the gastrectomized patients than in the healthy controls. The intestinal flora and environment were more disrupted in the totally gastrectomized than in the partially gastrectomized patients.
Many gastrectomized patients with irregular bowel movements exhibited significant changes showing impaired intestinal microflora and metabolite levels.
我们进行了一项关于胃切除术后患者排便异常的调查。研究并比较了他们的排便频率、肠道菌群和肠道环境与健康对照组的差异。
首先，我们对 769 名患者和 312 名健康对照者（共 1081 名受试者）进行了一项关于排便的问卷调查。其次，我们对 190 例排便异常的胃切除术后患者和首次调查中确定的 31 例对照者进行了排便频率（通过调查结果评分评估便秘/腹泻状态）、肠道菌群和肠道环境评估。
第一步：769 例患者中，58%抱怨排便异常（便秘、腹泻或交替出现），其抱怨频率明显高于健康对照组（33%）（p<0.01）。第二步：胃切除术后患者粪便中最主要的专性厌氧菌和有害菌水平较低和较高，粪便 pH 值较低，粪便含水量较低，粪便中腐坏代谢物水平较高。与部分胃切除术后患者相比，全胃切除术后患者的肠道菌群和环境受到的破坏更为严重。
许多排便异常的胃切除术后患者表现出明显的肠道微生物群和代谢物水平受损的改变。
