Servicio de Neumonología, Piso 8, Hospital Universitario de Caracas, Universidad Central de Venezuela, Los Chaguaramos, 1030, Caracas, Venezuela.
Eur Respir J. 2012 Jul;40(1):28-36. doi: 10.1183/09031936.00141611. Epub 2012 Jan 26.
Little information exists regarding the epidemiology of the chronic bronchitis phenotype in unselected chronic obstructive pulmonary disease (COPD) populations. We examined the prevalence of the chronic bronchitis phenotype in COPD and non-COPD subjects from the PLATINO study, and investigated how it is associated with important outcomes. Post-bronchodilator forced expiratory volume in 1 s/forced vital capacity <0.70 was used to define COPD. Chronic bronchitis was defined as phlegm on most days, at least 3 months per year for ≥ 2 yrs. We also analysed another definition: cough and phlegm on most days, at least 3 months per year for ≥ 2 yrs. Spirometry was performed in 5,314 subjects (759 with and 4,554 without COPD). The proportion of subjects with and without COPD with chronic bronchitis defined as phlegm on most days, at least 3 months per year for ≥ 2 yrs was 14.4 and 6.2%, respectively. Using the other definition the prevalence was lower: 7.4% with and 2.5% without COPD. Among subjects with COPD, those with chronic bronchitis had worse lung function and general health status, and had more respiratory symptoms, physical activity limitation and exacerbations. Our study helps to understand the prevalence of the chronic bronchitis phenotype in an unselected COPD population at a particular time-point and suggests that chronic bronchitis in COPD is possibly associated with worse outcomes.
关于未选择慢性阻塞性肺疾病 (COPD) 人群中慢性支气管炎表型的流行病学信息很少。我们检查了 PLATINO 研究中 COPD 和非 COPD 患者中慢性支气管炎表型的患病率，并研究了它如何与重要结局相关。使用支气管扩张剂后 1 秒用力呼气量/用力肺活量 <0.70 来定义 COPD。慢性支气管炎定义为大多数日子有痰，至少 2 年中每年有≥3 个月。我们还分析了另一种定义：大多数日子咳嗽和有痰，至少 2 年中每年有≥3 个月。在 5314 名受试者中进行了肺量测定（759 名有 COPD，4554 名无 COPD）。大多数日子有痰，至少 2 年中每年有≥3 个月的慢性支气管炎患者中，有 COPD 和无 COPD 的比例分别为 14.4%和 6.2%。使用另一种定义，患病率较低：有 COPD 的为 7.4%，无 COPD 的为 2.5%。在 COPD 患者中，有慢性支气管炎的患者肺功能和一般健康状况较差，且有更多的呼吸道症状、体力活动受限和加重。我们的研究有助于了解特定时间点未选择 COPD 人群中慢性支气管炎表型的患病率，并表明 COPD 中的慢性支气管炎可能与更差的结局相关。
