N-乙基-N-甲酰基肼诱发小鼠肿瘤。

N-ethyl-N-formylhydrazine tumorigenesis in mice.

机构信息

Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68105, USA.

出版信息

Carcinogenesis. 1980 Jan;1(1):61-5. doi: 10.1093/carcin/1.1.61.

DOI:10.1093/carcin/1.1.61

Abstract

N-ethyl-N-formylhydrazine (EFH) was administered as a 0.02% solution in drinking water continuously for life to randomly bred Swiss mice, from 6 weeks of age. The treatment induced tumors of the lungs, blood vessels, liver, gall bladder and preputial glands. The tumor incidences in treated females for these five tissues were 98, 94, 0, 2 and 0%, whereas in the treated males they were 78, 64, 26, 8 and 10%, respectively. Histopathologically the lesions were adenomas and adenocarcinomas of the lungs, angiomas and angiosarcomas of blood vessels, benign hepatomas, liver cell carcinomas, adenomas and adenocarcinomas of the gall bladder, and squamous cell papillomas and carcinomas of preputial glands. The study is part of a structure activity relationship inquiry and proves the carcinogenicity of EFH, a structural homologue of N-methyl-N-formylhydrazine, an ingredient of the edible false morel mushroom.

摘要

N-乙基-N-甲酰基肼（EFH）以 0.02%的水溶液形式连续给予随机繁殖的瑞士小鼠，从 6 周龄开始，终身给药。该治疗引发了肺部、血管、肝脏、胆囊和包皮腺的肿瘤。接受治疗的雌性小鼠这五种组织的肿瘤发生率分别为 98%、94%、0%、2%和 0%，而接受治疗的雄性小鼠的肿瘤发生率分别为 78%、64%、26%、8%和 10%。组织病理学上，病变为肺部的腺瘤和腺癌、血管的血管瘤和血管肉瘤、良性肝细胞瘤、肝细胞癌、胆囊的腺瘤和腺癌以及包皮腺的鳞状细胞乳头状瘤和癌。该研究是结构活性关系研究的一部分，证明了 EFH 的致癌性，EFH 是食用假羊肚菌中 N-甲基-N-甲酰基肼的结构同系物。