低剂量N-甲基-N-甲酰肼对小鼠的致瘤作用。

The tumorigenic effect of low dose levels of N-methyl-N-formylhydrazine in mice.

作者信息

Toth B, Patil K

出版信息

Neoplasma. 1980;27(1):25-31.

Abstract

Solutions of 0.002 and 0.001% N-methyl-N-formylhydrazine (MFH) were given separately daily in drinking water to 6-week-old randomly bred Swiss mice for life. The treatments resulted in induction of tumors of the lungs, blood vessels, liver and gall bladder. The 0.002% solution gave rise to tumors of the above tissues in incidences of 76, 27, 28 and 11%, respectively, while the 0.001% solution induced tumors in incidences of 75, 23, 7 and 6%. Histopathologically, the neoplasms were adenomas and adenocarcinomas of lungs, angiomas and angiosarcomas of blood vessells, benign hepatomas, liver cell carcinomas and adenomas and adenocarcinomas of the gall bladder. MFH is an ingredient of the edible mushroom, the false morel Gyromitra esculenta. The present study proves the carcinogenicity of MFH administered at low dose levels. The possible environmental significance of the findings to the human population is discussed.

摘要

将0.002%和0.001%的N-甲基-N-甲酰肼（MFH）溶液分别每日添加到饮用水中，给予6周龄的随机繁殖瑞士小鼠，持续终生。这些处理导致肺部、血管、肝脏和胆囊肿瘤的发生。0.002%的溶液导致上述组织肿瘤的发生率分别为76%、27%、28%和11%，而0.001%的溶液诱导肿瘤的发生率分别为75%、23%、7%和6%。组织病理学上，肿瘤为肺部的腺瘤和腺癌、血管的血管瘤和血管肉瘤、良性肝癌、肝细胞癌以及胆囊的腺瘤和腺癌。MFH是可食用蘑菇——假羊肚菌（Gyromitra esculenta）的一种成分。本研究证明了低剂量水平施用MFH的致癌性。讨论了这些发现对人类可能的环境意义。