Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick, Canada E3B 5A3.
J Org Chem. 2012 Feb 3;77(3):1572-8. doi: 10.1021/jo2021345. Epub 2012 Jan 23.
The synthesis and characterization of extended, conjugated molecules containing isoindolinone units was explored. Nucleophilic cyclizations between an amide and an alkyne were found to be an efficient method of producing the desired isoindolin-1-ones in high yields. A variety of derivatives were synthesized, demonstrating that a number of structural alterations could be made while maintaining good regio- and stereospecificity in the cyclized product.
探索了含有异吲哚啉酮单元的扩展共轭分子的合成和表征。发现酰胺和炔烃之间的亲核环化是高产率制备所需异吲哚-1-酮的有效方法。合成了多种衍生物，证明在保持环化产物良好区域和立体选择性的同时，可以进行许多结构改变。
