Department of Clinical Physiology, Nepal Medical College, Kathmandu, Nepal.
Acta Paediatr. 2012 Jun;101(6):671-6. doi: 10.1111/j.1651-2227.2012.02613.x. Epub 2012 Feb 23.
This study was undertaken to assess the nutritional status of 6-10 years old Nepalese children by measuring some haematological and biochemical parameters.
Nutritional status was assessed by height-for-age z-score. Total count of red blood corpuscles (TC of RBC), packed cell volume, haemoglobin concentration, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration were measured. Biochemical parameters such as serum iron, total iron-binding capacity (TIBC), serum ferritin, serum transferrin, transferrin saturation (TS) and serum albumin were also measured. Serum folate and vitamin B(12) were measured in well-nourished and undernourished children.
TC of RBC, serum iron, serum ferritin, TS and serum albumin of stunted children were significantly lower (p < 0.05) than that of well-nourished children. MCV, MCH, TIBC and serum transferrin of stunted children were significantly higher (p < 0.05) than that of well-nourished children. Serum folate and vitamin B(12) values of stunted children were significantly lower (p < 0.001) than that of well-nourished children.
A mild iron deficiency was found in stunted Nepalese children. The serum ferritin has been identified as a sensitive marker for measurement of iron status in surveyed children. A deficiency of serum protein, serum folate and vitamin B(12) was also found in the undernourished Nepalese children.
本研究通过测量一些血液学和生化参数来评估 6-10 岁尼泊尔儿童的营养状况。
通过身高年龄 z 评分评估营养状况。测量红细胞总数(TC of RBC)、红细胞压积、血红蛋白浓度、平均红细胞体积(MCV)、平均红细胞血红蛋白(MCH)和平均红细胞血红蛋白浓度。还测量了血清铁、总铁结合能力(TIBC)、血清铁蛋白、血清转铁蛋白、转铁蛋白饱和度(TS)和血清白蛋白等生化参数。在营养良好和营养不良的儿童中测量血清叶酸和维生素 B(12)。
身材矮小儿童的 RBC TC、血清铁、血清铁蛋白、TS 和血清白蛋白明显低于营养良好的儿童(p < 0.05)。身材矮小儿童的 MCV、MCH、TIBC 和血清转铁蛋白明显高于营养良好的儿童(p < 0.05)。身材矮小儿童的血清叶酸和维生素 B(12)值明显低于营养良好的儿童(p < 0.001)。
在身材矮小的尼泊尔儿童中发现了轻度缺铁。血清铁蛋白已被确定为测量调查儿童铁状况的敏感标志物。在营养不良的尼泊尔儿童中还发现了血清蛋白、血清叶酸和维生素 B(12)的缺乏。