Jafari Nodoshan A H, Hashemi A, Golzar A, Karami F, Akhondzaraini R
Iran J Ped Hematol Oncol. 2016;6(1):38-42. Epub 2016 Mar 15.
Non-organic failure to thrive (NFTT) is the most common cause of failure to thrive (FTT) which is attributed to inadequate nutrition due to economic factors or parental neglect . NFTT can lead to a vicious cycle of poor and inadequate eating and severity of anemia. The aim of this study was to determine the hematological indices in children with NFTT.
In a cross sectional case control study, iron status and blood indices of forty five aged 6-60 months children with NFTT were evaluated and compared with 45 healthy control children (with matching of age and sex).
In this study, the prevalence of anemia was 48.9% in NFTT compared to 11.4% in the control group (p<0.001). Microcytic anemia was significantly more prevalent among the subjects than the controls (77.8% versus 27.3%; p<0. 001). The serum iron level was 73.2 and 62.8 mcg/dl for the case and control groups (P=0.29). The ferritin level in the study group was 29.8 versus 35.47 ng/ml in the control group (p=0.227). The prevalence of iron deficiency anemia among children with mild, moderate, and severe underweight was 44.4%, 45.5%, and 48%, respectively. The highest prevalence of iron-deficiency anemia was seen between age group of 12 and 24 months (p<0.05).
Based on the results of this study, a correlation between malnutrition and anemia was found. However, further studies are needed to assess and confirm the current outcomes.
非器质性生长发育不良（NFTT）是生长发育不良（FTT）最常见的原因，其归因于经济因素或父母忽视导致的营养不足。NFTT可导致饮食不良和不足以及贫血严重程度的恶性循环。本研究的目的是确定NFTT患儿的血液学指标。
在一项横断面病例对照研究中，对45名6至60个月大的NFTT患儿的铁状态和血液指标进行评估，并与45名健康对照儿童（年龄和性别匹配）进行比较。
在本研究中，NFTT患儿的贫血患病率为48.9%，而对照组为11.4%（p<0.001）。小细胞性贫血在研究对象中比对照组更为普遍（77.8%对27.3%；p<0.001）。病例组和对照组的血清铁水平分别为73.2和62.8 mcg/dl（P=0.29）。研究组的铁蛋白水平为29.8 ng/ml，对照组为35.47 ng/ml（p=0.227）。轻度、中度和重度体重不足儿童的缺铁性贫血患病率分别为44.4%、45.5%和48%。缺铁性贫血患病率最高的是12至24个月年龄组（p<0.05）。
基于本研究结果，发现营养不良与贫血之间存在相关性。然而，需要进一步研究来评估和证实当前的结果。
