巴西中部结核病患者丙型肝炎病毒感染情况。

Hepatitis C virus infection in patients with tuberculosis in Central Brazil.

机构信息

Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goás, Brazil.

出版信息

Int J Tuberc Lung Dis. 2011 Oct;15(10):1397-402. doi: 10.5588/ijtld.10.0636.

DOI:10.5588/ijtld.10.0636

PMID:22283901

Abstract

SETTING

Goiânia City, Goiás State, Brazil.

OBJECTIVES

To determine the prevalence of hepatitis C virus (HCV) infection, risk factors, HCV genotype/ subtype, HCV viral load and human immunodeficiency virus (HIV) status in patients with tuberculosis (TB) in Central Brazil.

DESIGN

A cross-sectional study was carried out with 402 patients who were under tuberculosis (TB) treatment in the reference hospital for infectious diseases in Goiânia, Goiás, Central Brazil.

RESULTS

The prevalence rates of HCV and HIV were respectively 7.5% and 27.6%. Two thirds of the HCV-infected patients (20/30) were HIV-positive. Age, injecting drug use (IDU) and HIV status were factors independently associated with HCV infection. HCV RNA was detected in 23 serum samples; HCV RNA levels were measured in 22/23 samples. HCV RNA level was slightly higher in HCV-HIV co-infected patients than in HCV monoinfected patients. Genotypes 1 (n = 17) and 3 (n = 6) were determined by LiPA. Using phylogenetic tree analysis of the NS5B region, subtypes 1a (n = 12), 1b (n = 2) and 3a (n = 6) were identified.

CONCLUSION

These data indicate that patients with TB may benefit from integrated HIV and HCV screening, which may have an important impact upon TB management and treatment.

摘要

背景

巴西戈亚斯州戈亚尼亚市。

目的

在巴西中部，确定肺结核（TB）患者中丙型肝炎病毒（HCV）感染、危险因素、HCV 基因型/亚型、HCV 病毒载量和人类免疫缺陷病毒（HIV）状态的流行率。

设计

横断面研究共纳入 402 例在戈亚尼亚传染病参考医院接受结核病（TB）治疗的患者。

结果

HCV 和 HIV 的流行率分别为 7.5%和 27.6%。三分之二的 HCV 感染患者（20/30）HIV 阳性。年龄、注射吸毒（IDU）和 HIV 状态是与 HCV 感染相关的独立因素。23 份血清样本中检测到 HCV RNA；22/23 份样本中测量了 HCV RNA 水平。HCV-HIV 合并感染患者的 HCV RNA 水平略高于 HCV 单感染患者。LiPA 确定了基因型 1（n = 17）和 3（n = 6）。通过 NS5B 区的系统进化树分析，鉴定出 1a 型（n = 12）、1b 型（n = 2）和 3a 型（n = 6）亚型。