Gedefie Alemu, Seid Abdurahaman, Molla Fenta Genet, Tilahun Mihret, Shibabaw Agumas, Ali Abdurrahman
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
SAGE Open Med. 2023 Apr 25;11:20503121231166642. doi: 10.1177/20503121231166642. eCollection 2023.
Viral hepatitis, particularly hepatitis B virus and hepatitis C virus, is the leading cause of global liver-related morbidity and mortality. Concomitant infections of hepatitis B virus, hepatitis C virus, and tuberculosis are risks of hepatotoxicity and death due to antituberculosis therapy. Hepatitis and human immunodeficiency virus coinfection poses challenges in treating hepatotoxic patients and leads to mortality during antituberculosis treatment. Thus, this study aimed to determine the prevalence of hepatitis B virus and hepatitis C virus infections, and associated factors among human immunodeficiency virus-positive and human immunodeficiency virus-negative tuberculosis patients attending public health facilities, Northeast Ethiopia.
A comparative cross-sectional study was conducted among 229 tuberculosis patients from January 1 to April 30, 2021 in public health facilities' tuberculosis treatment centers. Study participants were selected using a consecutive sampling technique. Data on sociodemographic and other risk factors were collected using an interviewer-based pretested questionnaire by trained data collectors. Anti-hepatitis C virus and hepatitis B surface antigen were determined in serum using enzyme-linked immunosorbent assay. Data were entered and analyzed using SPSS version 22. Logistic regression analysis was computed, and then variables with a value <0.05 were considered as statistically significant.
The overall hepatitis virus infection among human immunodeficiency virus-positive and human immunodeficiency virus-negative tuberculosis patients was 14.03% and 8.14%, respectively. The prevalence of hepatitis B virus infection in human immunodeficiency virus positives and human immunodeficiency virus negatives was 10.5% and 6.4% and hepatitis C virus infection in human immunodeficiency virus positives and human immunodeficiency virus negatives was 3.5% and 1.75%, respectively. Hepatitis B virus and hepatitis C virus coinfections were not observed. Older age, history of problematic alcohol use, history of blood transfusion, ear-noise piercing, and history of multiple heterosexual partners were predictors for the hepatitis virus infection.
Hepatitis virus infection increases morbidity and mortality of tuberculosis patients. Therefore, screening tuberculosis patients for hepatitis virus infection is necessary to reduce the risk of antituberculosis complications.
病毒性肝炎，尤其是乙型肝炎病毒和丙型肝炎病毒，是全球肝脏相关发病和死亡的主要原因。乙型肝炎病毒、丙型肝炎病毒和结核病的合并感染存在因抗结核治疗导致肝毒性和死亡的风险。肝炎与人类免疫缺陷病毒合并感染给肝毒性患者的治疗带来挑战，并导致抗结核治疗期间的死亡。因此，本研究旨在确定埃塞俄比亚东北部公共卫生机构中人类免疫缺陷病毒阳性和人类免疫缺陷病毒阴性结核病患者中乙型肝炎病毒和丙型肝炎病毒感染的患病率及相关因素。
2021年1月1日至4月30日，在公共卫生机构的结核病治疗中心对229例结核病患者进行了一项比较横断面研究。采用连续抽样技术选取研究参与者。由经过培训的数据收集人员使用基于访谈者的预测试问卷收集社会人口学和其他风险因素的数据。采用酶联免疫吸附试验测定血清中的抗丙型肝炎病毒和乙型肝炎表面抗原。使用SPSS 22版输入和分析数据。进行逻辑回归分析，然后将P值<0.05的变量视为具有统计学意义。
人类免疫缺陷病毒阳性和人类免疫缺陷病毒阴性结核病患者的总体肝炎病毒感染率分别为14.03%和8.14%。人类免疫缺陷病毒阳性和人类免疫缺陷病毒阴性患者中乙型肝炎病毒感染率分别为10.
