Department of Physical Education and Sports Science at Serres, Aristotle University of Thessaloniki, Greece.
Eur J Intern Med. 2012 Mar;23(2):137-42. doi: 10.1016/j.ejim.2011.10.020. Epub 2011 Nov 29.
Adipose-tissue derivatives, known as adipokines, have been involved in the inflammatory-mediated metabolic and cardiovascular disorders of type 2 diabetes mellitus (T2DM). This study examined the association between novel adipokines and self-reported physical activity, a potential anti-inflammatory mediator.
We enrolled 247 men and women with T2DM, free from overt cardiovascular disease. Based on a physical activity questionnaire, patients were classified into groups: A) sedentary, who did not report any physical activity or reported light activities<2 h/week and B) active, referring to low or moderate-intensity physical activities>2 h/week. Among them, 88 patients were randomly selected to perform a cardiorespiratory ergocycle testing. Clinical parameters, glycemic and lipid profiles, HOMA-IR, and serum levels of visfatin, apelin, vaspin, ghrelin and adiponectin were assessed.
With the exception of fat-mass, our groups did not differ in anthropometric parameters and pharmaceutical regimen. Active patients showed ameliorated glucose regulation, HOMA-IR, hsCRP and exercise capacity compared to sedentary counterparts (p<0.01). Active rather than sedentary patients showed lower visfatin (10.16±5.53 ng/ml vs 14.77±8.48 ng/ml, p=0.013), higher apelin (1.39±0.65 ng/ml vs 1.04±0.35 ng/ml, p=0.018) and adiponectin (11.82±3.06 μg/ml vs 7.81±2.11 μg/ml, p=0.033) levels. There were non-significant differences in the rest of parameters between groups. After adjusting for age, sex and BMI, physical activity along with hsCRP and ghrelin remained independent determinants of visfatin levels (R(2)=0.328, p=0.032), while physical activity was independently associated with apelin (R(2)=0.221, p=0.022).
Self-controlled physical activity of, even, moderate intensity ameliorates adipokines, such as visfatin, apelin and adiponectin, in patients with T2DM. Prospective interventional studies will confirm our results. The ClinicalTrials.gov identifier is: NCT00306176.
脂肪组织衍生因子，即脂肪因子，与 2 型糖尿病（T2DM）的炎症介导的代谢和心血管疾病有关。本研究探讨了新型脂肪因子与自我报告的体力活动之间的关系，体力活动是一种潜在的抗炎介质。
我们招募了 247 名患有 T2DM 且无明显心血管疾病的男性和女性。根据体力活动问卷，患者被分为两组：A）久坐组，既不报告任何体力活动，也不报告每周<2 小时的轻体力活动；B）活跃组，指每周进行>2 小时的低强度或中等强度体力活动。其中，88 名患者被随机选择进行心肺运动测试。评估临床参数、血糖和血脂谱、HOMA-IR 以及血清内脏脂肪素、apelin、vaspin、ghrelin 和脂联素水平。
除脂肪量外，我们的两组在人体测量参数和药物治疗方案方面没有差异。与久坐组相比，活跃组的血糖调节、HOMA-IR、hsCRP 和运动能力得到改善（p<0.01）。与久坐组相比，活跃组患者的内脏脂肪素水平较低（10.16±5.53 ng/ml 比 14.77±8.48 ng/ml，p=0.013），apelin 水平较高（1.39±0.65 ng/ml 比 1.04±0.35 ng/ml，p=0.018），脂联素水平较高（11.82±3.06 μg/ml 比 7.81±2.11 μg/ml，p=0.033）。两组之间其余参数无显著差异。在校正年龄、性别和 BMI 后，体力活动以及 hsCRP 和 ghrelin 仍然是内脏脂肪素水平的独立决定因素（R²=0.328，p=0.032），而体力活动与 apelin 独立相关（R²=0.221，p=0.022）。
即使是中等强度的自我控制体力活动也能改善 T2DM 患者的脂肪因子，如内脏脂肪素、apelin 和脂联素。前瞻性干预性研究将证实我们的结果。临床试验注册号：NCT00306176。
