Doctoral School of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
Faculty of Health Sciences, University of Pécs, 7621 Pécs, Hungary.
Int J Mol Sci. 2023 May 3;24(9):8195. doi: 10.3390/ijms24098195.
Apelin, as a cardiokine/myokine, is emerging as an important regulator of cardiac and skeletal muscle homeostasis. Loss of apelin signaling results in premature cardiac aging and sarcopenia. However, the contribution of apelin to peak athletic performance remains largely elusive. In this paper, we assessed the impact of maximal cardiorespiratory exercise testing on the plasma apelin levels of 58 male professional soccer players. Circulating apelin-13 and apelin-36, on average, increased transiently after a single bout of treadmill exercise; however, apelin responses (Δapelin = peak - baseline values) showed a striking interindividual variability. Baseline apelin-13 levels were inversely correlated with those of Δapelin-13 and Δapelin-36. Δapelin-13 showed a positive correlation with the maximal metabolic equivalent, relative maximal O consumption, and peak circulatory power, whereas such an association in the case of Δapelin-36 could not be detected. In conclusion, we observed a pronounced individual-to-individual variation in exercise-induced changes in the plasma levels of apelin-13 and apelin-36. Since changes in plasma apelin-13 levels correlated with the indicators of physical performance, whole-body oxygen consumption and pumping capability of the heart, apelin, as a novel exerkine, may be a determinant of peak athletic performance.
Apelin 作为一种心激素/肌激素，正成为心脏和骨骼肌稳态的重要调节因子。Apelin 信号的缺失会导致心脏过早衰老和肌肉减少症。然而，Apelin 对运动表现峰值的贡献仍然很大程度上难以捉摸。在本文中，我们评估了最大心肺运动测试对 58 名男性职业足球运动员血浆 Apelin 水平的影响。循环 Apelin-13 和 Apelin-36 平均在一次跑步机运动后短暂增加；然而，Apelin 反应（ΔApelin = 峰值-基线值）表现出显著的个体间可变性。基线 Apelin-13 水平与 ΔApelin-13 和 ΔApelin-36 呈负相关。ΔApelin-13 与最大代谢当量、相对最大 O 消耗和峰值循环功率呈正相关，而在 Apelin-36 的情况下则无法检测到这种相关性。总之，我们观察到血浆 Apelin-13 和 Apelin-36 水平在运动诱导变化方面存在明显的个体间差异。由于血浆 Apelin-13 水平的变化与身体表现的指标相关，包括全身耗氧量和心脏泵血能力，作为一种新型的运动激素，Apelin 可能是运动表现峰值的决定因素。
