Newlands G F, MacKellar A, Miller H R
Moredun Research Institute, Edinburgh, U.K.
Int J Parasitol. 1990 Aug;20(5):669-72. doi: 10.1016/0020-7519(90)90125-7.
Immune reactions to enteric nematodes, in which mast cells are thought to play an important role, are abrogated following corticosteroid treatment of host animals. This is probably due, at least in part, to inhibition of cytokine production by T cells. It has proved difficult to block worm expulsion in mice with corticosteroids. We have therefore examined the effects of corticosteroids on mast cell numbers and concentrations of the mast cell granule-specific serine protease Mouse Intestinal Mast Cell Protease (MIMCP) in the intestines of mice infected with Nippostrongylus brasiliensis. Mucosal mast cell (MMC) numbers and concentrations of MIMCP were unaltered by steroid treatment. This is in marked contrast to Nippostrongylus-infected rats which showed decreases in both mast cell numbers and concentrations of the rat mucosal mast cell protease RMCP II after steroid treatment. This suggests that differentiated murine MMC are less dependent on T cells than those of the rat.
对肠道线虫的免疫反应中，肥大细胞被认为起着重要作用，宿主动物接受皮质类固醇治疗后这种免疫反应会被消除。这可能至少部分是由于T细胞产生的细胞因子受到抑制。事实证明，用皮质类固醇阻止小鼠体内的蠕虫排出很困难。因此，我们研究了皮质类固醇对感染巴西日圆线虫的小鼠肠道中肥大细胞数量以及肥大细胞颗粒特异性丝氨酸蛋白酶小鼠肠道肥大细胞蛋白酶（MIMCP）浓度的影响。类固醇治疗并未改变黏膜肥大细胞（MMC）的数量和MIMCP的浓度。这与感染巴西日圆线虫的大鼠形成鲜明对比，大鼠在接受类固醇治疗后，肥大细胞数量和大鼠黏膜肥大细胞蛋白酶RMCP II的浓度均有所下降。这表明分化后的小鼠MMC比大鼠的MMC对T细胞的依赖性更小。
