Division of Infectious Diseases, University of Kentucky School of Medicine, University of Kentucky, 800 Rose Street, MN-672, Lexington, KY 40536, USA.
Infect Dis Clin North Am. 2012 Mar;26(1):41-56. doi: 10.1016/j.idc.2011.09.004.
Prosthetic vascular grafting is a commonly performed procedure that is central to the management of arterial disease and renal failure. Though rare, vascular graft infections (VGI) are potentially devastating, and carry a high rate of mortality and amputation. Despite extensive research and clinical experience, VGI remain a daunting therapeutic challenge for surgeons and infectious disease specialists. This article reviews the pathogenesis of VGI, in particular the role of biofilms, as well as the current state of clinical management including diagnostic modalities, surgical options for treatment, antimicrobial therapy, and preventive measures.
人工血管移植是一种常见的手术，是动脉疾病和肾衰竭治疗的核心。虽然很少见，但血管移植物感染（VGI）可能具有破坏性，并导致高死亡率和截肢率。尽管进行了广泛的研究和临床经验，但 VGI 仍然是外科医生和传染病专家面临的严峻治疗挑战。本文回顾了 VGI 的发病机制，特别是生物膜的作用，以及目前的临床管理现状，包括诊断方法、治疗的手术选择、抗菌治疗和预防措施。
