伴有骨髓增生异常相关改变的急性髓系白血病（AML-MRC）中罕见的四倍体伴5号染色体长臂大片段缺失。 - Suppr

Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC).

作者信息

Jarosova Marie, Nedomova Radka, Hubacek Jaromir, Holzerova Milena, Mickova Pavla, Katrincsakova Beata, Pikalova Zuzana, Papajik Tomas, Indrak Karel

出版信息

Leuk Res. 2012 Apr;36(4):e68-70. doi: 10.1016/j.leukres.2011.12.014. Epub 2012 Jan 28.

DOI:10.1016/j.leukres.2011.12.014

PMID:22284693

Abstract

摘要

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Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC).伴有骨髓增生异常相关改变的急性髓系白血病（AML-MRC）中罕见的四倍体伴5号染色体长臂大片段缺失。

Leuk Res. 2012 Apr;36(4):e68-70. doi: 10.1016/j.leukres.2011.12.014. Epub 2012 Jan 28.

Molecular characterization of deletions of the long arm of chromosome 5 (del(5q)) in 94 MDS/AML patients.94例骨髓增生异常综合征/急性髓系白血病患者5号染色体长臂缺失（del(5q)）的分子特征分析

Leukemia. 2012 Jul;26(7):1695-7. doi: 10.1038/leu.2012.9. Epub 2012 Jan 17.

Fluorescence in situ hybridization for del(5q) in myelodysplasia/acute myeloid leukemia: comparison of EGR1 vs. CSF1R probes and diagnostic yield over metaphase cytogenetics alone.骨髓增生异常综合征/急性髓系白血病中 del(5q)的荧光原位杂交：EGR1 与 CSF1R 探针的比较及与单独中期细胞遗传学相比的诊断收益。

Leuk Res. 2010 Mar;34(3):340-3. doi: 10.1016/j.leukres.2009.05.026. Epub 2009 Jul 15.

Incidence of 17p deletions and TP53 mutation in myelodysplastic syndrome and acute myeloid leukemia with 5q deletion.5q 缺失的骨髓增生异常综合征和急性髓系白血病中 17p 缺失和 TP53 突变的发生率。

Genes Chromosomes Cancer. 2012 Dec;51(12):1086-92. doi: 10.1002/gcc.21993. Epub 2012 Aug 30.

Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression.接受来那度胺治疗后未能获得持续红细胞或细胞遗传学缓解的 del(5q) MDS 患者，其克隆进化和 AML 进展的风险增加。

Ann Hematol. 2010 Apr;89(4):365-74. doi: 10.1007/s00277-009-0846-z. Epub 2009 Oct 24.

Delineation by molecular cytogenetics of 5q deletion breakpoints in myelodyplastic syndromes and acute myeloid leukemia.通过分子细胞遗传学对骨髓增生异常综合征和急性髓系白血病中5q缺失断点的描绘。

Cancer Genet Cytogenet. 2006 May;167(1):66-9. doi: 10.1016/j.cancergencyto.2005.08.003.

Association of the type of 5q loss with complex karyotype, clonal evolution, TP53 mutation status, and prognosis in acute myeloid leukemia and myelodysplastic syndrome.5q 缺失类型与急性髓系白血病和骨髓增生异常综合征中复杂核型、克隆进化、TP53 突变状态和预后的相关性。

Genes Chromosomes Cancer. 2014 May;53(5):402-10. doi: 10.1002/gcc.22151. Epub 2014 Feb 3.

Myelodysplastic syndrome with del (5q) and JAK2(V617F) mutation transformed to acute myeloid leukaemia with complex karyotype.伴有5号染色体长臂缺失（del(5q)）和JAK2（V617F）突变的骨髓增生异常综合征转化为具有复杂核型的急性髓系白血病。

Ann Hematol. 2016 Feb;95(3):525-7. doi: 10.1007/s00277-015-2584-8. Epub 2016 Jan 11.

Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-.荧光原位杂交技术提高了骨髓增生异常综合征中5q31缺失的检测率，而这些病例并无5q-的细胞遗传学证据。

Haematologica. 2008 Jul;93(7):1001-8. doi: 10.3324/haematol.13012.

A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG).一种新的复发性易位，t(5;11)(q35;p15.5)，与儿童急性髓系白血病中的5号染色体长臂缺失(del(5q))相关。英国癌症细胞遗传学组(UKCCG)。

Blood. 1999 Jul 15;94(2):773-80.

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Rare Cytogenetic Abnormalities and Alteration of microRNAs in Acute Myeloid Leukemia and Response to Therapy.急性髓系白血病中罕见的细胞遗传学异常及微小RNA改变与治疗反应

Oncol Rev. 2015 Mar 9;9(1):261. doi: 10.4081/oncol.2015.261. eCollection 2015 Feb 10.

Two cases of near-tetraploidy in acute leukemias of ambiguous lineage.两例谱系不明的急性白血病中的近四倍体病例。

Ann Lab Med. 2013 Sep;33(5):371-4. doi: 10.3343/alm.2013.33.5.371. Epub 2013 Aug 8.

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Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC).

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