Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.
Sleep Med. 2012 Mar;13(3):285-9. doi: 10.1016/j.sleep.2011.07.018. Epub 2012 Jan 30.
This study aims to investigate the risk of psoriasis or psoriatic arthritis in patients with obstructive sleep apnea (OSA) compared with age- and gender-matched unaffected individuals, using a nationally representative population-based dataset.
We used data from the Taiwan "Longitudinal Health Insurance Database 2000." The study consisted of 2258 patients with OSA and 11,255 matched comparison patients as the study cohort. Each selected subject (n=13,513) in this study was individually traced for a three-year period from their index ambulatory care visits to identify patients who had been diagnosed with psoriasis during the follow-up period. A stratified Cox proportional hazard regression was used to compute the risk of psoriasis between patients with and without OSA.
It showed that, of 13,513 sampled subjects, 0.27% (n=36) had psoriasis during the three-year follow-up period; the percentage was 0.49% and 0.22% for sampled subjects with and without OSA, respectively. After adjusting for the patients' monthly incomes, geographic location, urbanization level, and obesity, the hazard of psoriasis during the three-year follow-up period was 2.30 (95% CI=1.13-4.69, p=0.022) times greater for patients with OSA than for comparison patients.
Our results suggest that OSA is associated with an increased risk of subsequent psoriasis or psoriatic arthritis.
本研究旨在使用全国代表性的基于人群的数据集，调查阻塞性睡眠呼吸暂停（OSA）患者与年龄和性别匹配的未受影响个体相比发生银屑病或银屑病关节炎的风险。
我们使用了来自台湾“2000 年纵向健康保险数据库”的数据。研究包括 2258 例 OSA 患者和 11255 例匹配的对照患者作为研究队列。本研究中每个入选的受试者（n=13513）都在他们的门诊就诊后的三年内进行个体追踪，以确定在随访期间被诊断为银屑病的患者。采用分层 Cox 比例风险回归计算 OSA 患者与非 OSA 患者之间发生银屑病的风险。
在 13513 名抽样受试者中，0.27%（n=36）在三年的随访期间患有银屑病；在有和没有 OSA 的抽样受试者中，这一比例分别为 0.49%和 0.22%。在调整了患者的月收入、地理位置、城市化水平和肥胖后，在三年的随访期间，患有 OSA 的患者发生银屑病的风险是对照组患者的 2.30 倍（95%CI=1.13-4.69，p=0.022）。
我们的结果表明，OSA 与随后发生银屑病或银屑病关节炎的风险增加有关。
