Leibovici J, Michowitz M, Argaman H
Department of Pathology, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Invasion Metastasis. 1990;10(5):289-300.
Tumor progression has been reported to be often accompanied by a loss of sensitivity to various elements of the immune system. In the present study, three variants of malignancy of AKR lymphoma were compared as to the host reaction they elicit. Splenectomy caused an acceleration of growth of the low-metastasizing tumor, slightly inhibited the growth of the tumor of intermediate malignancy and significantly inhibited the development of the high-metastasizing lymphoma. These results suggest that splenic elements exert an inhibitory effect on the low-metastasizing tumor and a growth-stimulatory effect on the more malignant ones. While decreased sensitivity to various host defense mechanisms following tumor progression has been amply documented, the present study shows a more severe phenomenon: increased malignancy can be accompanied by a deviation of the host immune reaction from tumor growth inhibition to growth stimulation.
据报道，肿瘤进展常伴随着对免疫系统各种成分敏感性的丧失。在本研究中，比较了AKR淋巴瘤三种恶性变体引发的宿主反应。脾切除术导致低转移肿瘤生长加速，对中度恶性肿瘤的生长略有抑制，对高转移淋巴瘤的发展有显著抑制作用。这些结果表明，脾脏成分对低转移肿瘤发挥抑制作用，对恶性程度更高的肿瘤发挥生长刺激作用。虽然肿瘤进展后对各种宿主防御机制的敏感性降低已有充分记录，但本研究显示了一种更严重的现象：恶性程度增加可能伴随着宿主免疫反应从抑制肿瘤生长转向刺激肿瘤生长的偏差。
