在两种小鼠肿瘤模型系统中，比较脾切除术作为宿主对原发性和转移性肿瘤细胞生长反应指标的效果。
Comparison of splenectomy effects as an indication for host response to growth of primary and metastatic tumour cells in two murine tumour systems.
作者信息
Michowitz M, Donin N, Sinai J, Leibovici J
机构信息
Department of Surgery C, Tel-Aviv Sourasky Medical Center, Israel.
出版信息
Int J Exp Pathol. 1995 Feb;76(1):13-9.
The tumour-host relation is of extreme complexity; moreover, it may change during tumour progression. Information regarding this relation may be of importance in appreciating the efficiency of immunotherapy. In the present study, the effect of splenectomy on tumour growth in two murine tumour progression models, the Lewis lung carcinoma and AKR lymphoma, was examined. The effect of spleen ablation on growth of cells derived from primary and metastatic tumour cells was tested. The data obtained showed a differential effect of splenectomy on the growth of primary versus metastatic tumour cells in the two tumour systems, indicating a differential host response induced by the two cell types and/or a differential tumour cell sensitivity to immune reactions. Surprisingly, the spleen appeared to have a defensive role against metastatic tumour cells and a growth enhancing influence on primary tumour cells. The instability of the tumour-host relation may have important implications for the chances of immunotherapy to serve as an efficient cancer treatment.
肿瘤与宿主的关系极其复杂；此外，它可能在肿瘤进展过程中发生变化。关于这种关系的信息对于理解免疫疗法的疗效可能具有重要意义。在本研究中，研究了脾切除术对两种小鼠肿瘤进展模型（Lewis肺癌和AKR淋巴瘤）中肿瘤生长的影响。测试了脾脏切除对源自原发性和转移性肿瘤细胞的细胞生长的影响。获得的数据表明，脾切除术对两种肿瘤系统中原发性肿瘤细胞与转移性肿瘤细胞生长的影响存在差异，这表明两种细胞类型诱导的宿主反应不同和/或肿瘤细胞对免疫反应的敏感性不同。令人惊讶的是，脾脏似乎对转移性肿瘤细胞具有防御作用，而对原发性肿瘤细胞具有促进生长的影响。肿瘤与宿主关系的不稳定性可能对免疫疗法作为一种有效的癌症治疗方法的可能性具有重要影响。
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