Faculdade de Veterinária, UFPel, Pelotas, RS, Brazil.
Vaccine. 2012 Mar 9;30(12):2173-7. doi: 10.1016/j.vaccine.2012.01.007. Epub 2012 Jan 26.
In recent years, there been significant progress toward develop more efficient vaccines. Different compounds with adjuvant capacity have been tested; however, no compound has emerged that suitable for universal use. Several efforts have been made to produce effective vaccines against Bovine herpesvirus 5 (BoHV-5), an important cattle pathogen. In this study we examine the use the probiotic Bacillus cereus var. Toyoi as a potential adjuvant to improve BoHV-5 vaccine efficacy. We observed in the supplemented animals a systemic enhanced IgG antibody response toward Th1, and increased IFN-γ, IL-12 and IL-10 cytokines mRNA levels. These results suggest that this probiotic could provide a promising means of improving vaccine efficacy, particularly those vaccines that rely on a cell-mediated immune response.
近年来，在开发更有效的疫苗方面取得了重大进展。已经测试了具有佐剂能力的不同化合物；然而，还没有出现适合普遍使用的化合物。人们已经做出了一些努力来生产针对牛疱疹病毒 5（BoHV-5）的有效疫苗，牛疱疹病毒 5 是一种重要的牛病原体。在这项研究中，我们研究了使用益生菌蜡样芽孢杆菌 var。Toyoi 作为一种潜在的佐剂来提高 BoHV-5 疫苗的功效。我们观察到在补充动物中，针对 Th1 的系统增强 IgG 抗体反应，以及增加 IFN-γ、IL-12 和 IL-10 细胞因子的 mRNA 水平。这些结果表明，这种益生菌可能提供一种有前途的提高疫苗功效的方法，特别是那些依赖细胞介导免疫反应的疫苗。
