Laboratory of Cellular and Molecular Physiology, University of Liège, 1 Avenue de l'Hôpital (B34), Sart Tilman, Liège, B-4000, Belgium.
Vaccine. 2012 Mar 9;30(12):2116-24. doi: 10.1016/j.vaccine.2012.01.039. Epub 2012 Jan 27.
Staphylococcus (S.) aureus is a major pathogen involved in chronic bovine mastitis. Staphylococcal mastitis is difficult to control due to the ability of S. aureus to invade and survive within host cells. We therefore postulated that induction of CD8(+) cytotoxic T lymphocyte (CTL) responses leading to destruction of infected cells could help in the control of S. aureus mastitis. We demonstrate that immunization of mice with heat-killed S. aureus together with agonistic anti-CD40 monoclonal antibodies elicits strong CTL responses capable of reducing the severity of subsequent staphylococcal mastitis. Our study shows promise for CTL-dependent vaccination against S. aureus mastitis.
金黄色葡萄球菌（S. aureus）是引起慢性牛乳腺炎的主要病原体。由于金黄色葡萄球菌能够侵入和在宿主细胞内生存，因此金黄色葡萄球菌乳腺炎难以控制。因此，我们假设诱导导致感染细胞破坏的 CD8(+)细胞毒性 T 淋巴细胞（CTL）反应有助于控制金黄色葡萄球菌乳腺炎。我们证明，用热灭活的金黄色葡萄球菌与激动性抗 CD40 单克隆抗体一起免疫小鼠可引发强大的 CTL 反应，能够减轻随后金黄色葡萄球菌乳腺炎的严重程度。我们的研究为 CTL 依赖性金黄色葡萄球菌乳腺炎疫苗接种提供了希望。
