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B 细胞相关表面分子 CD40 的简史。

A Short History of the B-Cell-Associated Surface Molecule CD40.

机构信息

Department of Immunology, University of Washington , Seattle, WA , USA.

出版信息

Front Immunol. 2014 Sep 29;5:472. doi: 10.3389/fimmu.2014.00472. eCollection 2014.

DOI:10.3389/fimmu.2014.00472
PMID:25324844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4179537/
Abstract

This perspective traces developments using monoclonal antibody technology that led to the discovery of CD40, a receptor that on B cells mediates "T cell help" and on dendritic cells helps to program CD8 T cell responses. I discuss some things that we got right during the path of discovery and some things we missed. Immunotherapies that block or stimulate the CD40 pathway hold great promise for treatment of autoimmune diseases and cancers.

摘要

这篇观点文章追溯了单克隆抗体技术的发展历程，该技术导致了 CD40 的发现，CD40 是一种受体，在 B 细胞上介导“T 细胞辅助”，在树突状细胞上有助于编程 CD8 T 细胞反应。我讨论了在发现过程中我们做对的一些事情和错过的一些事情。阻断或刺激 CD40 途径的免疫疗法为治疗自身免疫性疾病和癌症带来了巨大的希望。

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本文引用的文献

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Plasticity and complexity of B cell responses against persisting pathogens.针对持续性病原体的B细胞反应的可塑性与复杂性。
Immunol Lett. 2014 Nov;162(1 Pt A):53-8. doi: 10.1016/j.imlet.2014.07.003. Epub 2014 Jul 25.
2
Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.辅助性T细胞可塑性：外在和内在信号对转录组和表观基因组的影响
Curr Top Microbiol Immunol. 2014;381:279-326. doi: 10.1007/82_2014_371.
3
Locally delivered CD40 agonist antibody accumulates in secondary lymphoid organs and eradicates experimental disseminated bladder cancer.局部递送的 CD40 激动剂抗体在次级淋巴器官中积累，并根除实验性播散性膀胱癌。
Cancer Immunol Res. 2014 Jan;2(1):80-90. doi: 10.1158/2326-6066.CIR-13-0067. Epub 2013 Oct 21.
4
Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.新型抗 CD40L 结构域抗体的工程改造用于治疗自身免疫性疾病。
J Immunol. 2014 May 1;192(9):4083-92. doi: 10.4049/jimmunol.1303239. Epub 2014 Mar 26.
5
Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases.联合抗 CD40 和抗 IL-23 单克隆抗体治疗可有效抑制肿瘤生长和转移。
Cancer Res. 2014 May 1;74(9):2412-21. doi: 10.1158/0008-5472.CAN-13-1646. Epub 2014 Feb 20.
6
Anti-CD40-mediated cancer immunotherapy: an update of recent and ongoing clinical trials.抗 CD40 介导的癌症免疫疗法：近期和正在进行的临床试验更新。
Immunopharmacol Immunotoxicol. 2014 Apr;36(2):96-104. doi: 10.3109/08923973.2014.890626. Epub 2014 Feb 21.
7
Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer.CD40 激动型抗体免疫疗法中缓释系统的疗效。
Vaccine. 2014 Mar 26;32(15):1654-60. doi: 10.1016/j.vaccine.2014.01.056. Epub 2014 Feb 7.
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Costimulatory pathways in kidney transplantation: pathogenetic role, clinical significance and new therapeutic opportunities.肾移植中的共刺激途径：发病机制作用、临床意义和新的治疗机会。
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