血清 S100B 蛋白水平预测轻度颅脑损伤的颅内病变。
Serum levels of protein S100B predict intracranial lesions in mild head injury.
机构信息
U.O. Pronto Soccorso e Medicina d'Urgenza, Dipartimento di Emergenza-Urgenza, Azienda Ospedaliero-Universitaria di Parma, Italy.
出版信息
Clin Biochem. 2012 Apr;45(6):408-11. doi: 10.1016/j.clinbiochem.2012.01.006. Epub 2012 Jan 18.
OBJECTIVES
This study was aimed to assess whether serum S100B levels at emergency department admission can be used to omit unnecessary computed tomography (CT) in patients with minor head injury (MHI).
DESIGN AND METHODS
Sixty consecutive patients with recent MHI were included in this study. Serum S100B measurement and CT scanning were performed in all patients within 3h from head injury.
RESULTS
A positive CT scan was present in 20 out of 60 subjects. Significantly higher values of protein S100B were found in CT positive than in CT negative patients (1.35 versus 0.48 μg/L; p<0.001). The area under the ROC curve for protein S100B was highly significant (AUC 0.80; p<0.001) and a S100B cut-off value of 0.38 μg/L displayed 100% sensitivity and 58% specificity.
CONCLUSIONS
Serum S100-B levels might allow to omit unnecessary CT in patients with pure MHI, thus reducing radiation exposure and saving healthcare resources.
目的
本研究旨在评估入院时血清 S100B 水平是否可用于排除轻度头部损伤（MHI）患者的不必要 CT 检查。
设计和方法
本研究纳入了 60 例连续的近期 MHI 患者。所有患者在头部受伤后 3 小时内进行血清 S100B 测量和 CT 扫描。
结果
60 例患者中，20 例 CT 扫描阳性。CT 阳性患者的 S100B 蛋白值明显高于 CT 阴性患者（1.35 与 0.48 μg/L；p<0.001）。S100B 蛋白的 ROC 曲线下面积具有高度显著性（AUC 0.80；p<0.001），S100B 截断值为 0.38 μg/L 时具有 100%的敏感性和 58%的特异性。
结论
血清 S100-B 水平可能允许排除单纯 MHI 患者的不必要 CT 检查，从而减少辐射暴露并节省医疗保健资源。
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