Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Neuroepidemiology. 2012;38(2):76-83. doi: 10.1159/000335496. Epub 2012 Jan 27.
Multiple sclerosis (MS) patients may be at increased risk of venous thromboembolism (VTE), but evidence is limited.
To examine long-term risk of VTE among MS patients.
We conducted a population-based cohort study among 17,418 Danish MS patients and 87,090 comparison cohort members from the general population. Data on MS, VTE and comorbidities were obtained from the Danish National Registry of Patients including all admissions to Danish hospitals since 1977. We computed cumulative risks for VTE and adjusted incidence rate ratios (IRRs).
A total of 34 (0.2%) MS patients and 36 (0.04%) comparison cohort members had a deep venous thrombosis (DVT) within 1 year following the date of initial MS diagnosis/index date [adjusted IRR = 3.02 (95% CI: 2.14-4.27)]. During this period, 16 (0.09%) MS patients and 26 (0.03%) comparison cohort members had a documented pulmonary embolism (PE) [adjusted IRR = 2.85 (95% CI: 1.72-4.70)]. During the subsequent up to 29 years, 315 (1.9% of MS patients alive at year 1) MS patients had a record of a DVT [adjusted IRR = 2.28 (95% CI: 2.01-2.59)] and 129 (0.8%) had PE [IRR = 1.58 (95% CI: 1.31-1.92].
MS is a risk factor for VTE, but the absolute risk is low.
多发性硬化症（MS）患者发生静脉血栓栓塞症（VTE）的风险可能会增加，但证据有限。
研究 MS 患者发生 VTE 的长期风险。
我们在丹麦开展了一项基于人群的队列研究，共纳入 17418 名 MS 患者和 87090 名来自普通人群的对照组成员。MS、VTE 和合并症的数据来自丹麦国家患者登记处，包括自 1977 年以来所有在丹麦医院的住院记录。我们计算了 VTE 的累积风险，并调整了发病率比（IRR）。
在初始 MS 诊断/索引日期后 1 年内，共有 34 名（0.2%）MS 患者和 36 名（0.04%）对照组成员发生深静脉血栓形成（DVT）[调整后的 IRR=3.02（95%CI：2.14-4.27）]。在此期间，16 名（0.09%）MS 患者和 26 名（0.03%）对照组成员有记录的肺栓塞（PE）[调整后的 IRR=2.85（95%CI：1.72-4.70）]。在随后的 29 年中，315 名（1 年后存活的 MS 患者的 1.9%）MS 患者有 DVT 记录[调整后的 IRR=2.28（95%CI：2.01-2.59）]，129 名（0.8%）有 PE[IRR=1.58（95%CI：1.31-1.92）]。
MS 是 VTE 的一个危险因素，但绝对风险较低。
