Blyuss Konstantin B
Department of Mathematics, University of Sussex, Falmer, Brighton BN1 9QH, UK.
J Math Biol. 2013 Jan;66(1-2):115-37. doi: 10.1007/s00285-012-0508-y.
In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of interactions between different antigenic variants. The results of this analysis are quite generic, and have wider implications for understanding the dynamics of immune escape of other parasites, as well as for the dynamics of multi-strain diseases.
在病原体动力学及其与宿主免疫系统相互作用的研究中，与病原体相关的抗原变异体结构起着重要作用。以疟疾抗原变异模型为例，我们展示了如何根据不同抗原变异体之间相互作用的对称性来解释许多观察到的动力学机制。这一分析结果具有相当的普遍性，对于理解其他寄生虫的免疫逃逸动力学以及多菌株疾病的动力学具有更广泛的意义。
