Klassen Andrea M, Zimbelmann Michael, Lüken Sabine, Cremers Florian, Rades Dirk, Chronopoulos Argyrios, Rommel Felix, Ranjbar Mahdy, Grisanti Salvatore, Kakkassery Vinodh
Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Klinik für Strahlentherapie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Deutschland.
Ophthalmologie. 2022 Oct;119(10):1085-1096. doi: 10.1007/s00347-022-01730-3. Epub 2022 Sep 29.
Malignant tumors of the eye can be successfully treated with radiotherapy, which, however, can lead to radiogenic side effects in the surrounding healthy tissues. A distinction can be made between two forms of irradiation, external radiotherapy (teletherapy) and brachytherapy with a radiation source close to the tumor. The radiation dose is important for the occurrence of side effects. Acute damage usually results from inflammatory processes initiated at the cellular level. In contrast, late side effects are rather due to the reaction of the tissue with repair and remodeling processes . Acute side effects often resolve completely, especially under corresponding treatment, whereas late side effects tend to be irreversible. The aim of this article is to present risk factors as well as the clinical signs of periocular and ocular radiogenic side effects for the relevant tissue structures of the eye in a narrative review to facilitate ophthalmologic follow-up and, if necessary, treatment measures for these patients during everyday practice.
眼部恶性肿瘤可以通过放射治疗成功治愈，然而，放射治疗会导致周围健康组织产生放射性副作用。放射治疗可分为两种形式，即外部放射治疗（远距离治疗）和近距离放射治疗，后者使用靠近肿瘤的放射源。辐射剂量对副作用的发生很重要。急性损伤通常是由细胞水平引发的炎症过程导致的。相比之下，晚期副作用更多是由于组织的修复和重塑过程引起的反应。急性副作用通常会完全消退，尤其是在相应治疗下，而晚期副作用往往是不可逆的。本文旨在通过叙述性综述介绍眼周和眼部放射性副作用对眼部相关组织结构的危险因素及临床体征，以便在日常实践中促进对这些患者的眼科随访，并在必要时采取治疗措施。
