Department of Chemistry, Indian Institute of Technology, Roorkee-247 667, Uttarakhand, India.
Org Biomol Chem. 2012 Mar 14;10(10):1958-61. doi: 10.1039/c2ob06681e. Epub 2012 Jan 27.
Highly reactive o-benzoquinone monoimines were chemically generated and successfully trapped with electron-rich olefins that led to the synthesis of hitherto unknown 1,4-benzoxazine derivatives. This unprecedented transformation was achieved by the oxidation of o-aminophenols bearing appropriate functionality on the arene residue with less expensive hypervalent iodine reagent in the presence of vinylic ethers or thioethers.
高反应性邻苯醌单亚胺通过化学方法生成，并成功地与富电子烯烃捕获，导致了前所未知的 1,4-苯并恶嗪衍生物的合成。这种前所未有的转化是通过在烯丙基醚或硫醚存在下，用较便宜的高价碘试剂氧化芳基残留物上带有适当官能团的邻氨基酚来实现的。
