Cetın Bülent, Büyükberber Süleyman, Yilmaz Işılay Bilge, Yildiz Ramazan, Coşkun Uğur, Beneklı Mustafa
Gazi University, School of Medicine, Department of Internal Medicine Division of Medical Oncology, Ankara, Turkey.
Turk J Gastroenterol. 2011 Dec;22(6):621-5. doi: 10.4318/tjg.2011.0280.
Kaposi's sarcoma is an unusual tumor principally affecting the skin of the lower extremities. Although the association between Kaposi's sarcoma and renal transplant has been well documented, there are few Kaposi's sarcoma cases in the literature associated with ulcerative colitis or other inflammatory bowel diseases. This report presents a patient with ulcerative colitis who developed Kaposi's sarcoma following treatment with long-term medium-dose azathioprine and additional corticosteroids. Kaposi's sarcoma is a rare complication in inflammatory bowel diseases that may (or may not) be related to immunosuppression. Hence, immunomodulatory agents should be planned carefully in the treatment of inflammatory bowel diseases and avoided if they are not essentially necessary. Cases of colorectal Kaposi's sarcoma complicating inflammatory bowel disease should be managed with a conservative approach and discontinuation of the immunosuppressive treatment.
卡波西肉瘤是一种罕见肿瘤，主要累及下肢皮肤。虽然卡波西肉瘤与肾移植之间的关联已有充分记录，但文献中很少有与溃疡性结肠炎或其他炎症性肠病相关的卡波西肉瘤病例。本报告介绍了一名溃疡性结肠炎患者，该患者在长期接受中剂量硫唑嘌呤及额外皮质类固醇治疗后发生了卡波西肉瘤。卡波西肉瘤是炎症性肠病中的一种罕见并发症，可能（或可能不）与免疫抑制有关。因此，在炎症性肠病的治疗中应谨慎规划免疫调节药物的使用，若非必要应避免使用。炎症性肠病并发结直肠卡波西肉瘤的病例应采用保守方法处理，并停用免疫抑制治疗。
