The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.
J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1435-43. doi: 10.1002/jbm.b.32662. Epub 2012 Jan 28.
Periodontal regeneration is defined as regeneration of the tooth-supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes.
牙周组织再生是指包括牙骨质、牙周膜和牙槽骨在内的牙齿支持组织的再生。引导组织再生（GTR）已被证明是实现牙周组织再生的有效技术。在 GTR 手术中，各种膜起着重要作用。壳聚糖是甲壳素的脱乙酰衍生物，具有生物相容性、可生物降解性和抗菌性。它作为保湿剂，具有组织修复和骨诱导作用。壳聚糖可以很容易地加工成膜、凝胶、纳米纤维、珠粒、纳米粒子、支架和海绵形式，并可用于药物输送系统。在这里，我们综述了壳聚糖的生物特性，并报告了壳聚糖作为 GTR 和引导骨再生（GBR）膜的应用进展，表明壳聚糖可能是一种很好的基质候选材料，可作为 GTR/GBR 膜的材料。
