Dr. Rumina Tabassum, FCPS, Associate Professor of Obs & Gynae, Dow University of Health Sciences (DUHS), Karachi, Pakistan.
Dr. Fouzia Imtiaz, PhD, Associate Professor of Biochemistry, Dow University of Health Sciences (DUHS), Karachi, Pakistan.
Pak J Med Sci. 2013 Apr;29(2):593-6. doi: 10.12669/pjms.292.3180.
The aim was to estimate the prevalence of Insulin Resistance (IR) in Poly Cystic Ovary Syndrome (PCOS) and analyze its clinical parameters.
This observational study was conducted at Dow University Hospital during June 2011 till May 2012. Patients of PCOS were selected, an anthropometric measurement, examination and fasting blood test for sugar (FBS) and insulin was performed. Data was collected on pre designed questionnaire, was analyzed by SPSS version 16.
Forty-six cases of PCOS were included in the study. Prevalence of IR was 34.78%. Mean age of patients was 23.72 ± 4.37 years. Waist Hip Ratio (WHR) was raised in 42 (91.30%), acanthosis was found in 26(56.50%), impaired FBS was seen in 9 (19.6%) and raised fasting insulin in 16 (34.8%) patients. There was significant association between acanthosis and WHR (0.044) and between acanthosis and FBS (0.008). Correlation studies between parameters showed a significant correlation between Waist & Hips (0.93), similarly Waist & WHR showed positive correlation (0.59), at p< 0.01. Significant positive correlation was also found between waist and FBS (0.32) and FBS & WHR (0.378).
Acanthosis nigrican, raised WHR and FBS are significant parameters for insulin resistance in cases of Poly Cystic Ovary Syndrome (PCOS).
评估多囊卵巢综合征（PCOS）患者胰岛素抵抗（IR）的患病率，并分析其临床参数。
本观察性研究于 2011 年 6 月至 2012 年 5 月在道大学医院进行。选择 PCOS 患者，进行人体测量学测量、检查和空腹血糖（FBS）及胰岛素空腹检查。数据由预先设计的问卷收集，使用 SPSS 版本 16 进行分析。
本研究纳入了 46 例 PCOS 患者。IR 的患病率为 34.78%。患者的平均年龄为 23.72±4.37 岁。42 例（91.30%）患者的腰臀比（WHR）升高，26 例（56.50%）患者出现黑棘皮病，9 例（19.6%）患者 FBS 受损，16 例（34.8%）患者空腹胰岛素升高。黑棘皮病与 WHR（0.044）和黑棘皮病与 FBS（0.008）之间存在显著相关性。参数之间的相关性研究表明，腰围与臀围之间存在显著相关性（0.93），腰围与 WHR 之间也呈正相关（0.59），p<0.01。腰围与 FBS（0.32）和 FBS 与 WHR（0.378）之间也存在显著正相关。
黑棘皮病、升高的 WHR 和 FBS 是多囊卵巢综合征（PCOS）患者胰岛素抵抗的重要参数。
