Essah P A, Nestler J E
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980111, Richmond, 23298-0111, USA.
J Endocrinol Invest. 2006 Mar;29(3):270-80. doi: 10.1007/BF03345554.
Much overlap is present between the polycystic ovary syndrome (PCOS) and the metabolic syndrome. This article reviews the existing data regarding the prevalence, characteristics, and treatment of the metabolic syndrome in women with PCOS. The prevalence of the metabolic syndrome in PCOS is approximately 43-47%, a rate 2-fold higher than that for women in the general population. High body mass index and low serum HDL cholesterol are the most frequently occurring components of the metabolic syndrome in PCOS. The pathogenic link between the metabolic syndrome and PCOS is most likely insulin resistance. Therefore, the presence of the metabolic syndrome in PCOS suggests a greater degree of insulin resistance compared to PCOS without the metabolic syndrome. Obesity, atherogenic dyslipidemia, hypertension, impaired fasting glucose/impaired glucose tolerance, and vascular abnormalities are all common metabolic abnormalities present in PCOS. Lifestyle modification has proven benefit and pharmacological therapy with insulin-sensitizing agents has potential benefit in the treatment of the metabolic syndrome in women with PCOS.
多囊卵巢综合征（PCOS）与代谢综合征之间存在诸多重叠之处。本文回顾了有关PCOS女性中代谢综合征的患病率、特征及治疗的现有数据。PCOS中代谢综合征的患病率约为43%-47%，这一比率比普通人群中的女性高出2倍。高体重指数和低血清高密度脂蛋白胆固醇是PCOS中代谢综合征最常见的组成部分。代谢综合征与PCOS之间的致病联系很可能是胰岛素抵抗。因此，与无代谢综合征的PCOS相比，PCOS中代谢综合征的存在提示胰岛素抵抗程度更高。肥胖、致动脉粥样硬化血脂异常、高血压、空腹血糖受损/糖耐量受损以及血管异常都是PCOS中常见的代谢异常情况。生活方式改变已被证明有益，使用胰岛素增敏剂进行药物治疗对PCOS女性代谢综合征的治疗具有潜在益处。
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