Jacobs David J, Pathengay Avinash, Flynn Harry W, Leng Theodore, Miller Darlene, Shi Wei
Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Int J Inflam. 2012;2012:503912. doi: 10.1155/2012/503912. Epub 2012 Jan 11.
Purpose. To report the visual acuity (VA) outcomes and culture results of delayed-onset bleb-associated endophthalmitis (BAE) with and without intravitreal dexamethasone (IVD). Methods. Retrospective nonrandomized comparative case series of BAE at Bascom Palmer Eye Institute between January 1, 1996 and December 31, 2009. Clinical data were compared using the 2-sided Student's t-test for patients who received IVD and patients who did not receive IVD. Results. 70/83 (84%) received IVD, and 13/83 (16%) did not receive IVD. Mean baseline VA was 20/90 in the IVD group and 20/70 in the group that did not receive IVD (P = 0.57). Mean presenting VA was 0.9/200 in the IVD group and 1.7/200 in the group that did not receive IVD (P = 0.23). Repeat cultures were positive in 2/70 (3%) IVD cases and 1/13 (8%) cases that did not receive IVD (P = 0.57). Mean VA at 1 month was 5/200 in the IVD group and 1.8/200 in the group that did not receive IVD, logMARΔ of 0.85 and 1.56, respectively (P = 0.02). Mean VA at 3 months was 7/200 in the IVD group and 3/200 in the group that did not receive IVD, logMARΔ of 0.74 and 1.33, respectively (P = 0.14). Conclusion. In the current study of BAE, IVD was associated with improved short-term VA outcomes without an increased rate of persistent infection.
目的。报告有和没有玻璃体内注射地塞米松（IVD）的迟发性滤过泡相关眼内炎（BAE）的视力（VA）结果和培养结果。方法。对1996年1月1日至2009年12月31日在巴斯科姆·帕尔默眼科研究所的BAE进行回顾性非随机对照病例系列研究。使用双侧学生t检验对接受IVD和未接受IVD的患者的临床数据进行比较。结果。83例中有70例（84%）接受了IVD，13例（16%）未接受IVD。IVD组的平均基线视力为20/90，未接受IVD组为20/70（P = 0.57）。IVD组的平均就诊时视力为0.9/200，未接受IVD组为1.7/200（P = 0.23）。重复培养在2/70例（3%）接受IVD的病例和1/13例（8%）未接受IVD的病例中呈阳性（P = 0.57）。IVD组1个月时的平均视力为5/200，未接受IVD组为1.8/200，对数最小分辨角变化（logMARΔ）分别为0.85和1.56（P = 0.02）。IVD组3个月时的平均视力为7/200，未接受IVD组为3/200，logMARΔ分别为0.74和1.33（P = 0.14）。结论。在当前关于BAE的研究中，IVD与短期视力结果改善相关，且持续性感染率未增加。
