• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

孕期药物治疗:己烯雌酚、沙利度胺和反应停的教训

Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.

作者信息

Saunders E J, Saunders J A

出版信息

Health Care Women Int. 1990;11(4):423-32. doi: 10.1080/07399339009515912.

DOI:10.1080/07399339009515912
PMID:2228814
Abstract

A pregnant woman and the fetus she carries face health risks from many sources. One risk that requires ongoing vigilance is the use of prescription drugs during pregnancy. The international health care community has been sensitized to the risks of drug use during pregnancy because of three pharmaceuticals that have caused widespread crises for mothers and their offspring. The crises that diethylstilbestrol, thalidomide, and, to a lesser extent, Bendectin have created in the past four decades are reviewed in this article. The lessons these drug crises can teach us are articulated in the belief that similar crises may be averted in the future.

摘要

孕妇及其腹中胎儿面临着诸多健康风险。其中一项需要持续警惕的风险便是孕期使用处方药。由于三种药物曾给母亲及其后代造成广泛危机,国际医疗界已开始关注孕期用药的风险。本文将回顾己烯雌酚、沙利度胺以及(程度稍轻的)苯海拉明在过去四十年间引发的危机。我们坚信,从这些药物危机中吸取的教训能够让我们避免未来可能出现的类似危机。

相似文献

1
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.孕期药物治疗:己烯雌酚、沙利度胺和反应停的教训
Health Care Women Int. 1990;11(4):423-32. doi: 10.1080/07399339009515912.
2
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.无辜旁观者。多西拉敏/双环维林/吡哆醇与先天性肢体缺陷。
Med J Aust. 1984 Apr 28;140(9):525-7.
3
Additional follow-up of congenital limb disorders in relation to Bendectin use.
JAMA. 1983 Jul 1;250(1):33-4.
4
Debendox is not thalidomide.
Lancet. 1984 Jul 28;2(8396):205-6.
5
Bendectin and birth defects: hopefully, the final chapter.多潘立酮与出生缺陷:希望这是最后一章。 (注:你提供的原文中“Bendectin”一般指的是多潘立酮,不过从医学专业角度看,多潘立酮与出生缺陷并无关联,这里可能存在信息误差,正常医学文献中关于多潘立酮的内容不会提及与出生缺陷的关系。如果“Bendectin”另有正确指代,请根据实际情况调整译文。)
Birth Defects Res A Clin Mol Teratol. 2003 Feb;67(2):79-87. doi: 10.1002/bdra.10021.
6
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.多潘立酮与出生缺陷:I. 流行病学研究的荟萃分析。
Teratology. 1994 Jul;50(1):27-37. doi: 10.1002/tera.1420500105.
7
Debendox in the dock.复方晕海宁(乘晕宁)被送上了法庭。
Nurs Mirror. 1980 Feb 21;150(8):8-9.
8
Bendectin case dismissed.“曲美苄胺案”撤诉。
Science. 1995 Jan 13;267(5195):167. doi: 10.1126/science.7809619.
9
The Bendectin debate.关于“弯迪生”的争论。
Can Med Assoc J. 1980 Nov 8;123(9):922-8.
10
[2 cases of malformations of a limb in infants of mothers treated with an antiemetic in a very early phase of pregnancy].[孕期极早期使用止吐药治疗的母亲所生婴儿出现2例肢体畸形]
Pediatr Med Chir. 1981 Jan-Feb;3(1):97-9.

引用本文的文献

1
Development of lactation and breast/chestfeeding adverse event terminology (LaBAET) through a Delphi consensus approach.通过德尔菲共识法制定泌乳及母乳喂养不良事件术语(LaBAET)。
Int Breastfeed J. 2025 Jul 4;20(1):53. doi: 10.1186/s13006-025-00743-3.
2
Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors.含异恶唑的溴结构域和额外末端结构域(BET)抑制剂的生物活化
Metabolites. 2021 Jun 15;11(6):390. doi: 10.3390/metabo11060390.
3
The Sex-Gender Effects in the Road to Tailored Botanicals.性别的影响在定制植物药的道路上。
Nutrients. 2019 Jul 17;11(7):1637. doi: 10.3390/nu11071637.
4
Botanicals and Their Bioactive Phytochemicals for Women's Health.用于女性健康的植物药及其生物活性植物化学物质
Pharmacol Rev. 2016 Oct;68(4):1026-1073. doi: 10.1124/pr.115.010843.
5
Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects.醌类的形成及其生物学靶点:细胞毒性与细胞保护作用
Chem Res Toxicol. 2017 Jan 17;30(1):13-37. doi: 10.1021/acs.chemrestox.6b00256. Epub 2016 Sep 29.
6
Microphysiological modeling of the reproductive tract: a fertile endeavor.生殖道的微生理建模:一项富有成效的努力。
Exp Biol Med (Maywood). 2014 Sep;239(9):1192-202. doi: 10.1177/1535370214529387. Epub 2014 Apr 15.
7
The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics.妊娠中的药物代谢动力学现状:第三届美国药物代谢动力学会议要点。
Br J Clin Pharmacol. 2012 Dec;74(6):932-9. doi: 10.1111/j.1365-2125.2012.04280.x.
8
Aminopeptidase A inhibitors as centrally acting antihypertensive agents.氨肽酶A抑制剂作为中枢性抗高血压药物。
Heart Fail Rev. 2008 Sep;13(3):311-9. doi: 10.1007/s10741-007-9077-3. Epub 2008 Jan 3.
9
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension.全身活性氨肽酶A抑制剂对脑肾素-血管紧张素系统的阻断作用:盐依赖性高血压的一种潜在治疗方法。
Proc Natl Acad Sci U S A. 2004 May 18;101(20):7775-80. doi: 10.1073/pnas.0402312101. Epub 2004 May 10.
10
Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options?孕期及哺乳期胃食管反流病的治疗:最安全的治疗选择有哪些?
Drug Saf. 1998 Oct;19(4):325-37. doi: 10.2165/00002018-199819040-00007.