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阿尔茨海默病的转基因小鼠模型：作为治疗干预工具的更好模型的开发。

Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions.

机构信息

School of Natural Sciences, University of California, Merced, CA 95343, USA.

出版信息

Curr Pharm Des. 2012;18(8):1131-47. doi: 10.2174/138161212799315786.

DOI:10.2174/138161212799315786
PMID:22288400
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4437619/
Abstract

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies.

摘要

阿尔茨海默病（AD）是老年人痴呆症的主要病因。目前，AD 尚无有效的治疗方法。对 AD 转基因小鼠模型的分析促进了我们对疾病机制的理解，并为评估潜在治疗策略提供了有价值的工具。在这篇综述中，我们将讨论当前 AD 小鼠模型的优缺点及其对理解病理机制和开发有效疗法的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aab/4437619/1bd1adc56ac0/nihms-688863-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aab/4437619/1bd1adc56ac0/nihms-688863-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aab/4437619/1bd1adc56ac0/nihms-688863-f0001.jpg

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Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.γ-分泌酶的调制可减少阿尔茨海默病转基因小鼠模型中的β-淀粉样蛋白沉积。
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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.γ-分泌酶激活蛋白是阿尔茨海默病的治疗靶点。
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